If cytopathologists are used to dedicating 1 or more fine-needle aspiration passes to prepare a tumor-representative cell block, the testing laboratory may strongly rely on anaplastic lymphoma kinase (ALK), ROS proto-oncogene 1, receptor tyrosine kinase (ROS1), and programmed death-ligand 1 (PD-L1) immunocytochemistry assays. Conversely, when sample procurement and diagnostic interpretation are based primarily on smeared material, cytopathologists should promote, in conjunction with the molecular team, ALK and ROS1 RNA-based testing approaches on smears, saving the cell block only for PD-L1 staining
All-in-one: The dream and reality of molecular cytopathology testing on routine lung cancer smears / Troncone, Giancarlo. - In: CANCER CYTOPATHOLOGY. - ISSN 1934-662X. - 126:3(2018), pp. 155-157-157. [10.1002/cncy.21962]
All-in-one: The dream and reality of molecular cytopathology testing on routine lung cancer smears
Troncone, Giancarlo
2018
Abstract
If cytopathologists are used to dedicating 1 or more fine-needle aspiration passes to prepare a tumor-representative cell block, the testing laboratory may strongly rely on anaplastic lymphoma kinase (ALK), ROS proto-oncogene 1, receptor tyrosine kinase (ROS1), and programmed death-ligand 1 (PD-L1) immunocytochemistry assays. Conversely, when sample procurement and diagnostic interpretation are based primarily on smeared material, cytopathologists should promote, in conjunction with the molecular team, ALK and ROS1 RNA-based testing approaches on smears, saving the cell block only for PD-L1 stainingI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.