Background: Atransient dysfunction of the endocrine growth axis has been reported in celiac disease (CD). This apparent growth hormone deficiency (GHD) generally normalizes with the institution of a gluten-free diet (GFD). However, in few cases, the dysfunction of the GH axis persists despite a good adherence to the GFD. Aims of this study were to investigate pediatric patients with concurrent CDand GHDand to compare them with patients with isolated CD. Methods: Data regarding CDpatients with and without associated GHDwere retrospectively collected. Inclusion criteria were availability of anthropometric and laboratory data at baseline and regularly at the reference center up to a 2-year follow-up. In case of poor catch-up growth despite a good adherence to the GFD, endocrinological investigation was carried on. Results: Fifty-three patients with CDwere included. Four (7.5%) out of 53 CDpatients had a concurrent GHD. In two cases, firstly diagnosed with CD, GHD was suspected because of a poor catch-up growth despite a good adherence to the GFD. In two other cases, firstly diagnosed with GHD, gastrointestinal symptoms revealed the diagnosis of CD. Normalization of height velocity was achieved by GH treatment in all cases. No statistical significant difference between the two groups of patients was found as regard laboratory and histological features of CD. It is to note that 2 out of 4 patients with concomitant CDand GHDhad thyroiditis compared to 6% of patients with isolated CD(P=0.004). Conclusions: Ahigh prevalence of CDand GHDassociation was found. CDpatients with poor catch-up growth despite a good adherence to the GFDshould be carefully investigated for endocrine disorders.
A retrospective evaluation of the association of celiac disease and growth hormone deficiency: More than a casual association? / Giannattasio, Antonietta; Di dato, Fabiola; Minicucci, Valentina; Mariano, Miriam; Immacolata Spagnuolo, Maria; Macchiaroli, Annamaria; Iorio, Raffaele. - In: MINERVA ENDOCRINOLOGICA. - ISSN 0391-1977. - 42:1(2017), pp. 24-29. [10.23736/S0391-1977.16.02366-X]