Amnestic mild cognitive impairment (aMCI) is considered a prodromal stage of Alzheimer's disease (AD). We measured plasma levels of amyloid-beta40 (Abeta40) and Abeta42 in 191 subjects with aMCI. Seventy-nine of them were clinically followed for two years. In the total cohort of aMCI cases, the average level of Abeta42, as well as the Abeta42/Abeta40 ratio, was significantly higher than those of the 102 cognitively normal age-matched subjects. The aMCI cases that converted to probable AD within 2 years had higher levels of Abeta42 and, to a lesser extent, Abeta40 than the stable cases. However the large variability of measured values indicates that plasma Abeta is not a suitable marker of incipient AD.
Amyloid-beta42 plasma levels are elevated in amnestic mild cognitive impairment / Cammarata, Sergio; Borghi, Roberta; Giliberto, Luca; Pardini, Matteo; Pollero, Valeria; Novello, Cristina; Fornaro, Michele; Vitali, Antonella; Bracco, Laura; Caltagirone, Carlo; Bossù, Paola; Odetti, Patrizio; Tabaton, Massimo. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1875-8908. - 18:2(2009), p. 267-71. [10.3233/JAD-2009-1144]
Amyloid-beta42 plasma levels are elevated in amnestic mild cognitive impairment
Fornaro, Michele;
2009
Abstract
Amnestic mild cognitive impairment (aMCI) is considered a prodromal stage of Alzheimer's disease (AD). We measured plasma levels of amyloid-beta40 (Abeta40) and Abeta42 in 191 subjects with aMCI. Seventy-nine of them were clinically followed for two years. In the total cohort of aMCI cases, the average level of Abeta42, as well as the Abeta42/Abeta40 ratio, was significantly higher than those of the 102 cognitively normal age-matched subjects. The aMCI cases that converted to probable AD within 2 years had higher levels of Abeta42 and, to a lesser extent, Abeta40 than the stable cases. However the large variability of measured values indicates that plasma Abeta is not a suitable marker of incipient AD.File | Dimensione | Formato | |
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