The gastrointestinal microbiota plays a critical role in nutritional, metabolic, and immune functions in infants and young children and has implications for future lung health status. Understanding the role of intestinal dysbiosis in chronic lung disease progression will provide opportunities to design early interventions to improve the course of the disease. Gut microbiota is established within the first 1 to 3 years of life and remains relatively stable throughout the life span. In this review, we report the recent development in research in gut-lung axis, with focus on the effects of targeting microbiota of infants and children at risk of or with progressive lung diseases. The basic concept is to exploit this approach in critical window to achieve the best results in the control of future health.
Early-Life Intestine Microbiota and Lung Health in Children / Ranucci, Giusy; Buccigrossi, Vittoria; De Freitas, Maiara Brusco; Guarino, Alfredo; Giannattasio, Antonietta. - In: JOURNAL OF IMMUNOLOGY RESEARCH. - ISSN 2314-8861. - 2017:(2017), pp. 1-5. [10.1155/2017/8450496]
Early-Life Intestine Microbiota and Lung Health in Children
Ranucci, Giusy;Buccigrossi, Vittoria;Guarino, Alfredo;Giannattasio, Antonietta
2017
Abstract
The gastrointestinal microbiota plays a critical role in nutritional, metabolic, and immune functions in infants and young children and has implications for future lung health status. Understanding the role of intestinal dysbiosis in chronic lung disease progression will provide opportunities to design early interventions to improve the course of the disease. Gut microbiota is established within the first 1 to 3 years of life and remains relatively stable throughout the life span. In this review, we report the recent development in research in gut-lung axis, with focus on the effects of targeting microbiota of infants and children at risk of or with progressive lung diseases. The basic concept is to exploit this approach in critical window to achieve the best results in the control of future health.File | Dimensione | Formato | |
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