Guide to NMR Spectral Interpretation

This book is designed to provide undergraduate and graduate students with practical strategies, methods and explanations to unravel the intriguing combinations of chemical shift, integration, and multiplicity of NMR signals. In particular, it is organized in a way that basic 1H- and 13C-NMR concepts are introduced and immediately applied in a number of problems, solved and discussed in a step-by-step fashion. It contains almost exclusively real NMR data and it describes how to interpret the chemical shift, intensity and splitting pattern of the proton and carbon NMR signals (Chapters 1-5), paying attention to the effects of the magnetically non-equivalent nuclei (Chapter 4). The role of the solvent is also explained (Chapter 6), and a description of the interpretation of the most common two-dimensional NMR experiments is reported in Chapter 7. Chapter 8 is dedicated to the strategy for structural elucidation, while Chapter 9 contains exclusively summary problems with increasing levels of difficulty. The entire learning path is aimed to provide practical tools to determine the chemical structures of small organic molecules from their 1D and 2D NMR spectra.