Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Wain, Louise V.; Verwoert, Germaine C.; O'Reilly, Paul F.; Shi, Gang; Johnson, Toby; Johnson, Andrew D.; Bochud, Murielle; Rice, Kenneth M.; Henneman, Peter; Smith, Albert V.; Ehret, Georg B.; Amin, Najaf; Larson, Martin G.; Mooser, Vincent; Hadley, David; Dörr, Marcus; Bis, Joshua C; Aspelund, Thor; Esko, Tõnu; Janssens, A Cecile J. W.; Zhao, Jing Hua; Heath, Simon; Laan, Maris; Jingyuan, Fu; Pistis, Giorgio; Luan, Jian'An; Arora, Pankaj; Lucas, Gavin; Pirastu, Nicola; Pichler, Irene; Jackson, Anne U.; Webster, Rebecca J.; Zhang, Feng; Peden, John F.; Schmidt, Helena; Tanaka, Toshiko; Campbell, Harry; Igl, Wilmar; Milaneschi, Yuri; Hottenga, Jouke-Jan; Vitart, Veronique; Chasman, Daniel I.; Trompet, Stella; Bragg-Gresham, Jennifer L.; Alizadeh, Behrooz Z.; Chambers, John C.; Guo, Xiuqing; Lehtimäki, Terho; Kühnel, Brigitte; Lopez, Lorna M.; Polašek, Ozren; Boban, Mladen; Nelson, Christopher P.; Morrison, Alanna C.; Pihur, Vasyl; Ganesh, Santhi K.; Hofman, Albert; Kundu, Suman; Mattace-Raso, Francesco U. S.; Rivadeneira, Fernando; Sijbrands, Eric J. G.; Uitterlinden, Andre G.; Hwang, Shih-Jen; Vasan, Ramachandran S.; Wang, Thomas J.; Bergmann, Sven; Vollenweider, Peter; Waeber, Gérard; Laitinen, Jaana; Pouta, Anneli; Zitting, Paavo; Mcardle, Wendy L.; Kroemer, Heyo K.; Völker, Uwe; Völzke, Henry; Glazer, Nicole L.; Taylor, Kent D.; Harris, Tamara B.; Alavere, Helene; Haller, Toomas; Keis, Aime; Tammesoo, Mari-Liis; Aulchenko, Yurii; Barroso, In S.; Khaw, Kay-Tee; Galan, Pilar; Hercberg, Serge; Lathrop, Mark; Eyheramendy, Susana; Org, Elin; Sõber, Siim; Xiaowen, Lu; Nolte, Ilja M.; Penninx, Brenda W.; Corre, Tanguy; Masciullo, Corrado; Sala, Cinzia; Groop, Leif; Voight, Benjamin F; Melander, Olle; O'Donnell, Christopher J; Salomaa, Veikko; D'Adamo, Adamo Pio; Fabretto, Antonella; Faletra, Flavio; Ulivi, Sheila; Del Greco M, Fabiola; Facheris, Maurizio; Collins, Francis S.; Bergman, Richard N.; Beilby, John P.; Hung, Joseph; Musk, A William; Mangino, Massimo; Shin, So-Youn; Soranzo, Nicole; Watkins, Hugh; Goel, Anuj; Hamsten, Anders; Gider, Pierre; Loitfelder, Marisa; Zeginigg, Marion; Hernandez, Dena; Najjar, Samer S.; Navarro, Pau; Wild, Sarah H.; Corsi, Anna Maria; Singleton, Andrew; De Geus, Eco J. C.; Willemsen, Gonneke; Parker, Alex N.; Rose, Lynda M.; Buckley, Brendan; Stott, David; Orru, Marco; Uda, Manuela; Van Der Klauw, Melanie M.; Zhang, Weihua; Xinzhong, Li; Scott, James; Chen, Yii-Der Ida; Burke, Gregory L; Kähönen, Mika; Viikari, Jorma; Döring, Angela; Meitinger, Thomas; Davies, Gail; Starr, John M.; Emilsson, Valur; Plump, Andrew; Lindeman, Jan H.; Hoen, Peter A. C. T.; König, Inke R.; Felix, Janine F.; Clarke, Robert; Hopewell, Jemma C.; Ongen, Halit; Breteler, Monique; Debette, Stéphanie; Destefano, Anita L.; Fornage, Myriam; Mitchell, Gary F.; Smith, Nicholas L.; Holm, Hilma; Stefansson, Kari; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Samani, Nilesh J.; Preuss, Michael; Rudan, Igor; Hayward, Caroline; Deary, Ian J.; Wichmann, H-Erich; Raitakari, Olli T.; Palmas, Walter; Kooner, Jaspal S.; Stolk, Ronald P.; Jukema, J Wouter; Wright, Alan F.; Boomsma, Dorret I.; Bandinelli, Stefania; Gyllensten, Ulf B.; Wilson, James F.; Ferrucci, Luigi; Schmidt, Reinhold; Farrall, Martin; Spector, Tim D.; Palmer, Lyle J.; Tuomilehto, Jaakko; Pfeufer, Arne; Gasparini, Paolo; Siscovick, David; Altshuler, David; Loos, Ruth J. F.; Toniolo, Daniela; Snieder, Harold; Gieger, Christian; Meneton, Pierre; Wareham, Nicholas J.; Oostra, Ben A.; Metspalu, Andres; Launer, Lenore; Rettig, Rainer; Strachan, David P.; Beckmann, Jacques S.; Witteman, Jacqueline C. M.; Erdmann, Jeanette; Van Dijk, Ko Willems; Boerwinkle, Eric; Boehnke, Michael; Ridker, Paul M.; Jarvelin, Marjo-Riitta; Chakravarti, Aravinda; Abecasis, Goncalo R.; Gudnason, Vilmundur; Newton-Cheh, Christopher; Levy, Daniel; Munroe, Patricia B.; Psaty, Bruce M.; Caulfield, Mark J.; Rao, Dabeeru C.; Tobin, Martin D.; Elliott, Paul; Duijn, Van; McEniery CM, Cornelia M.; Wilkinson, Ib; Cockcroft, Jr; O'Shaughnessy, Km; Newhouse, Sj; Yasmin,; Smith, Av; Eiriksdottir, G; Launer, Lj; Sigurdsson, S; Aspelund, T; Gudnason, V; De Bacquer, D; Rietzschel, Er; De Backer GG,; Van Bortel, L; De Buyzere ML,; Segers, P; Bekaert, S; Gillebert, Tc; De Meyer, T; Ferrucci, L; Tanaka, T; Johnson, Ad; Levy, D; Benjamin, Ej; Mitchell, Gf; Vita, Ja; Larson, Mg; Hamburg, Nm; Vasan, Rs; Isaacs, A; Schut, Af; Oostra, Ba; van Duijn CM,; van Rijn MJ,; Sie, Mp; Newman, Ab; Herrington, Dm; Andrews, Js; Ding, J; Sutton-Tyrrell, Kc; Harris, Tb; Howard, Td; Liu, Y; Parsa, A; Shuldiner, Ar; Mcardle, Pf; Gibson, Q; Post, Ws; Dehghan, A; Hofman, A; Uitterlinden, Ag; Sijbrands, Ej; Rivadeneira, F; Mattace-Raso, Fu; Verwoert, Gc; Witteman, Jc; Scuteri, A; Lakatta, Eg; Jewell, E; Abecasis, Gr; Tarasov, Kv; Uda, M; Najjar, Ss; Sanna, S; Attwood, T; Belz, S; Braund, P; Cambien, F; Cooper, J; Crisp-Hihn, A; Deloukas, P; Foad, N; Eardman, J; Goodall, Ah; Gracey, J; Gray, E; Gulde, S; Gwilliams, R; Heimerl, S; Hengstenberg, C; Jolley, J; Krishnan, U; Linsel-Nitschke, P; Lloyd-Jones, H; Lugauer, I; Lundmark, P; Maouche, S; Moore, Js; Muir, D; Murray, E; Nelson, Cp; Neudert, J; Niblett, D; O'Leary, K; Ouwehand, Wh; Pollard, H; Rankin, A; Rice, Cm; Sager, H; Samani, Nj; Sambrook, J; Schmitz, G; Scholz, M; Schroeder, L; Schunkert, H; Syvannen, Ac; Wallace, C; Kathiresan, S; Reilly, Mp; Samani, Nj; Schunkert, H; Erdmann, J; Assimes, Tl; Boerwinkle, E; Erdmann, J; Hall, A; Hengstenberg, C; Kathiresan, S; König, Ir; Laaksonen, R; Mcpherson, R; Reilly, Mp; Samani, Nj; Schunkert, H; Thompson, Jr; Thorsteinsdottir, U; Ziegler, A; König, Ir; Thompson, Jr; Absher, D; Chen, L; Cupples, La; Halperin, E; M, Li; Musunuru, K; Preuss, M; Schillert, A; Thorleifsson, G; Voight, Bf; Wells, Ga; Assime, Tl; Deloukas, P; Erdmann, J; Holm, H; Kathiresan, S; König, Ir; Mcpherson, R; Reilly, Mp; Roberts, R; Samani, Nj; Schunkert, H; Stewart, Af; Absher, D; Assimes, Tl; Fortmann, S; A, Go; Hlatky, M; Iribarren, C; Knowles, J; Myers, R; Quertermous, T; Sidney, S; Risch, N; Tang, H; Blankenberg, S; Zeller, T; Schillert, A; Wild, P; Ziegler, A; Schnabel, R; Sinning, C; Lackner, K; Tiret, L; Nicaud, V; Cambien, F; Bickel, C; Rupprecht, Hj; Perret, C; Proust, C; Münzel, T; Barbalic, M; Bis, J; Boerwinkle, E; Chen, Iy; Cupples, L; Dehghan, A; Demissie-Banjaw, S; Folsom, A; Glazer, N; Gudnason, V; Harris, T; Heckbert, S; Levy, D; Lumley, T; Marciante, K; Morrison, A; O' Donnell CJ,; Psaty, Bm; Rice, K; Rotter, Ji; Siscovick, Ds; Smith, N; Smith, A; Taylor, Kd; van Duijn, C; Volcik, K; Whitteman, J; Ramachandran, V; Hofman, A; Uitterlinden, A; Gretarsdottir, S; Gulcher, Jr; Holm, H; Kong, A; Stefansson, K; Thorgeirsson, G; Andersen, K; Thorleifsson, G; Thorsteinsdottir, U; Erdmann, J; Fischer, M; Grosshennig, A; Hengstenberg, C; König, Ir; Lieb, W; Linsel-Nitschke, P; Preuss, M; Stark, K; Schreiber, S; Wichmann, He; Ziegler, A; Schunkert, H; Aherrahrou, Z; Bruse, P; Doering, A; Erdmann, J; Hengstenberg, C; Illig, T; Klopp, N; König, Ir; Linsel-Nitschke, P; Loley, C; Medack, A; Meisinger, C; Meitinger, T; Nahrstedt, J; Peters, A; Preuss, M; Stark, K; Wagner, Ak; Wichmann, He; Willenborg, C; Ziegler, A; Schunkert, H; Böhm, Bo; Dobnig, H; Grammer, Tb; Halperin, E; Hoffmann, Mm; Kleber, M; Laaksonen, R; März, W; Meinitzer, A; Winkelmann, Br; Pilz, S; Renner, W; Scharnagl, H; Stojakovic, T; Tomaschitz, A; Winkler, K; Voight, Bf; Musunuru, K; Guiducci, C; Burtt, N; Gabriel, Sb; Siscovick, Ds; O'Donnell, Cj; Elosua, R; Peltonen, L; Salomaa, V; Schwartz, Sm; Melander, O; Altshuler, D; Kathiresan, S; Stewart, Af; Chen, L; Dandona, S; Wells, Ga; Jarinova, O; Mcpherson, R; Roberts, R; Reilly, Mp; M, Li; L, Qu; Wilensky, R; Matthai, W; Hakonarson, Hh; Devaney, J; Burnett, Ms; Pichard, Ad; Kent, Km; Satler, L; Lindsay, Jm; Waksman, R; Knouff, Cw; Waterworth, Dm; Walker, Mc; Mooser, V; Epstein, Se; Rader, Dj; Samani, Nj; Thompson, Jr; Braund, Ps; Nelson, Cp; Wright, Bj; Balmforth, Aj; Ball, Sg; Hall, As; Smith, Nl; Felix, Jf; Morrison, Ac; Demissie, S; Glazer, Nl; Loehr, Lr; Cupples, La; Dehghan, A; Lumley, T; Rosamond, Wd; Lieb, W; Rivadeneira, F; Bis, Jc; Folsom, Ar; Benjamin, E; Aulchenko, Ys; Haritunians, T; Couper, D; Murabito, J; Yang, Ya; Stricker, Bh; Gottdiener, Js; Chang, Pp; Wang, Tj; Rice, Km; Hofman, A; Heckbert, Sr; Fox, Er; O'Donnell, Cj; Uitterlinden, Ag; Rotter, Ji; Willerson, Jt; Levy, D; van Duijn CM,; Psaty, Bm; Witteman, Jc; Boerwinkle, E; Vasan, Rs; Köttgen, A; Pattaro, C; Böger, Ca; Fuchsberger, C; Olden, M; Glazer, Nl; Parsa, A; Gao, X; Yang, Q; Smith, Av; O'Connell, Jr; M, Li; Schmidt, H; Tanaka, T; Isaacs, A; Ketkar, S; Hwang, Sj; Johnson, Ad; Dehghan, A; Teumer, A; Paré, G; Atkinson, Ej; Zeller, T; Lohman, K; Cornelis, Mc; Probst-Hensch, Nm; Kronenberg, F; Tönjes, A; Hayward, C; Aspelund, T; Eiriksdottir, G; Launer, Lj; Harris, Tb; Rampersaud, E; Mitchell, Bd; Arking, De; Boerwinkle, E; Struchalin, M; Cavalieri, M; Singleton, A; Giallauria, F; Metter, J; de Boer IH,; Haritunians, T; Lumley, T; Siscovick, D; Psaty, Bm; Zillikens, Mc; Oostra, Ba; Feitosa, M; Province, M; de Andrade, M; Turner, St; Schillert, A; Ziegler, A; Wild, Ps; Schnabel, Rb; Wilde, S; Munzel, Tf; Leak, Ts; Illig, T; Klopp, N; Meisinger, C; Wichmann, He; Koenig, W; Zgaga, L; Zemunik, T; Kolcic, I; Minelli, C; Fb, Hu; Johansson, A; Igl, W; Zaboli, G; Wild, Sh; Wright, Af; Campbell, H; Ellinghaus, D; Schreiber, S; Aulchenko, Ys; Felix, Jf; Rivadeneira, F; Uitterlinden, Ag; Hofman, A; Imboden, M; Nitsch, D; Brandstätter, A; Kollerits, B; Kedenko, L; Mägi, R; Stumvoll, M; Kovacs, P; Boban, M; Campbell, S; Endlich, K; Völzke, H; Kroemer, Hk; Nauck, M; Völker, U; Polasek, O; Vitart, V; Badola, S; Parker, An; Ridker, Pm; Kardia, Sl; Blankenberg, S; Liu, Y; Curhan, Gc; Franke, A; Rochat, T; Paulweber, B; Prokopenko, I; Wang, W; Gudnason, V; Shuldiner, Ar; Coresh, J; Schmidt, R; Ferrucci, L; Shlipak, Mg; van Duijn CM,; Borecki, I; Krämer, Bk; Rudan, I; Gyllensten, U; Wilson, Jf; Witteman, Jc; Pramstaller, Pp; Rettig, R; Hastie, N; Chasman, Di; Kao, Wh; Heid, Im; Fox, Cs; Vasan, Rs; Glazer, Nl; Felix, Jf; Lieb, W; Wild, Ps; Felix, Sb; Watzinger, N; Larson, Mg; Smith, Nl; Dehghan, A; Grosshennig, A; Schillert, A; Teumer, A; Schmidt, R; Kathiresan, S; Lumley, T; Aulchenko, Ys; König, Ir; Zeller, T; Homuth, G; Struchalin, M; Aragam, J; Bis, Jc; Rivadeneira, F; Erdmann, J; Schnabel, Rb; Dörr, M; Zweiker, R; Lind, L; Rodeheffer, Rj; Greiser, Kh; Levy, D; Haritunians, T; Deckers, Jw; Stritzke, J; Lackner, Kj; Völker, U; Ingelsson, E; Kullo, I; Haerting, J; O'Donnell, Cj; Heckbert, Sr; Stricker, Bh; Ziegler, A; Reffelmann, T; Redfield, Mm; Werdan, K; Mitchell, Gf; Rice, K; Arnett, Dk; Hofman, A; Gottdiener, Js; Uitterlinden, Ag; Meitinger, T; Blettner, M; Friedrich, N; Wang, Tj; Psaty, Bm; van Duijn CM,; Wichmann, He; Munzel, Tf; Kroemer, Hk; Benjamin, Ej; Rotter, Ji; Witteman, Jc; Schunkert, H; Schmidt, H; Völzke, H; Blankenberg, S; Chambers, Jc; Zhang, W; Lord, Gm; van der Harst, P; Lawlor, Da; Sehmi, Js; Gale, Dp; Wass, Mn; Ahmadi, Kr; Bakker, Sj; Beckmann, J; Bilo, Hj; Bochud, M; Brown, Mj; Caulfield, Mj; Connell, Jm; Cook, Ht; Cotlarciuc, I; Davey Smith, G; de Silva, R; Deng, G; Devuyst, O; Dikkeschei, Ld; Dimkovic, N; Dockrell, M; Dominiczak, A; Ebrahim, S; Eggermann, T; Farrall, M; Ferrucci, L; Floege, J; Forouhi, Ng; Gansevoort, Rt; Han, X; Hedblad, B; Homan van der Heide JJ,; Hepkema, Bg; Hernandez-Fuentes, M; Hypponen, E; Johnson, T; de Jong PE,; Kleefstra, N; Lagou, V; Lapsley, M; Y, Li; Loos, Rj; Luan, J; Luttropp, K; Maréchal, C; Melander, O; Munroe, Pb; Nordfors, L; Parsa, A; Peltonen, L; Penninx, Bw; Perucha, E; Pouta, A; Prokopenko, I; Roderick, Pj; Ruokonen, A; Samani, Nj; Sanna, S; Schalling, M; Schlessinger, D; Schlieper, G; Seelen, Ma; Shuldiner, Ar; Sjögren, M; Smit, Jh; Snieder, H; Soranzo, N; Spector, Td; Stenvinkel, P; Sternberg, Mj; Swaminathan, R; Tanaka, T; Ubink-Veltmaat, Lj; Uda, M; Vollenweider, P; Wallace, C; Waterworth, D; Zerres, K; Waeber, G; Wareham, Nj; Maxwell, Ph; Mccarthy, Mi; Jarvelin, Mr; Mooser, V; Abecasis, Gr; Lightstone, L; Scott, J; Navis, G; Elliott, P; Kooner, Js.

doi:10.1038/ng.922

Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P = 2.3 × 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure / Wain, Louise V.; Verwoert, Germaine C.; O'Reilly, Paul F.; Shi, Gang; Johnson, Toby; Johnson, Andrew D.; Bochud, Murielle; Rice, Kenneth M.; Henneman, Peter; Smith, Albert V.; Ehret, Georg B.; Amin, Najaf; Larson, Martin G.; Mooser, Vincent; Hadley, David; Dörr, Marcus; Bis, Joshua C; Aspelund, Thor; Esko, Tõnu; Janssens, A Cecile J. W.; Zhao, Jing Hua; Heath, Simon; Laan, Maris; Fu, Jingyuan; Pistis, Giorgio; Luan, Jian'An; Arora, Pankaj; Lucas, Gavin; Pirastu, Nicola; Pichler, Irene; Jackson, Anne U.; Webster, Rebecca J.; Zhang, Feng; Peden, John F.; Schmidt, Helena; Tanaka, Toshiko; Campbell, Harry; Igl, Wilmar; Milaneschi, Yuri; Hottenga, Jouke-Jan; Vitart, Veronique; Chasman, Daniel I.; Trompet, Stella; Bragg-Gresham, Jennifer L.; Alizadeh, Behrooz Z.; Chambers, John C.; Guo, Xiuqing; Lehtimäki, Terho; Kühnel, Brigitte; Lopez, Lorna M.; Polašek, Ozren; Boban, Mladen; Nelson, Christopher P.; Morrison, Alanna C.; Pihur, Vasyl; Ganesh, Santhi K.; Hofman, Albert; Kundu, Suman; Mattace-Raso, Francesco U. S.; Rivadeneira, Fernando; Sijbrands, Eric J. G.; Uitterlinden, Andre G.; Hwang, Shih-Jen; Vasan, Ramachandran S.; Wang, Thomas J.; Bergmann, Sven; Vollenweider, Peter; Waeber, Gérard; Laitinen, Jaana; Pouta, Anneli; Zitting, Paavo; Mcardle, Wendy L.; Kroemer, Heyo K.; Völker, Uwe; Völzke, Henry; Glazer, Nicole L.; Taylor, Kent D.; Harris, Tamara B.; Alavere, Helene; Haller, Toomas; Keis, Aime; Tammesoo, Mari-Liis; Aulchenko, Yurii; Barroso, In S.; Khaw, Kay-Tee; Galan, Pilar; Hercberg, Serge; Lathrop, Mark; Eyheramendy, Susana; Org, Elin; Sõber, Siim; Lu, Xiaowen; Nolte, Ilja M.; Penninx, Brenda W.; Corre, Tanguy; Masciullo, Corrado; Sala, Cinzia; Groop, Leif; Voight, Benjamin F; Melander, Olle; O'Donnell, Christopher J; Salomaa, Veikko; D'Adamo, Adamo Pio; Fabretto, Antonella; Faletra, Flavio; Ulivi, Sheila; Del Greco M, Fabiola; Facheris, Maurizio; Collins, Francis S.; Bergman, Richard N.; Beilby, John P.; Hung, Joseph; Musk, A William; Mangino, Massimo; Shin, So-Youn; Soranzo, Nicole; Watkins, Hugh; Goel, Anuj; Hamsten, Anders; Gider, Pierre; Loitfelder, Marisa; Zeginigg, Marion; Hernandez, Dena; Najjar, Samer S.; Navarro, Pau; Wild, Sarah H.; Corsi, Anna Maria; Singleton, Andrew; De Geus, Eco J. C.; Willemsen, Gonneke; Parker, Alex N.; Rose, Lynda M.; Buckley, Brendan; Stott, David; Orru, Marco; Uda, Manuela; Van Der Klauw, Melanie M.; Zhang, Weihua; Li, Xinzhong; Scott, James; Chen, Yii-Der Ida; Burke, Gregory L; Kähönen, Mika; Viikari, Jorma; Döring, Angela; Meitinger, Thomas; Davies, Gail; Starr, John M.; Emilsson, Valur; Plump, Andrew; Lindeman, Jan H.; Hoen, Peter A. C. T.; König, Inke R.; Felix, Janine F.; Clarke, Robert; Hopewell, Jemma C.; Ongen, Halit; Breteler, Monique; Debette, Stéphanie; Destefano, Anita L.; Fornage, Myriam; Mitchell, Gary F.; Smith, Nicholas L.; Holm, Hilma; Stefansson, Kari; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Samani, Nilesh J.; Preuss, Michael; Rudan, Igor; Hayward, Caroline; Deary, Ian J.; Wichmann, H-Erich; Raitakari, Olli T.; Palmas, Walter; Kooner, Jaspal S.; Stolk, Ronald P.; Jukema, J Wouter; Wright, Alan F.; Boomsma, Dorret I.; Bandinelli, Stefania; Gyllensten, Ulf B.; Wilson, James F.; Ferrucci, Luigi; Schmidt, Reinhold; Farrall, Martin; Spector, Tim D.; Palmer, Lyle J.; Tuomilehto, Jaakko; Pfeufer, Arne; Gasparini, Paolo; Siscovick, David; Altshuler, David; Loos, Ruth J. F.; Toniolo, Daniela; Snieder, Harold; Gieger, Christian; Meneton, Pierre; Wareham, Nicholas J.; Oostra, Ben A.; Metspalu, Andres; Launer, Lenore; Rettig, Rainer; Strachan, David P.; Beckmann, Jacques S.; Witteman, Jacqueline C. M.; Erdmann, Jeanette; Van Dijk, Ko Willems; Boerwinkle, Eric; Boehnke, Michael; Ridker, Paul M.; Jarvelin, Marjo-Riitta; Chakravarti, Aravinda; Abecasis, Goncalo R.; Gudnason, Vilmundur; Newton-Cheh, Christopher; Levy, Daniel; Munroe, Patricia B.; Psaty, Bruce M.; Caulfield, Mark J.; Rao, Dabeeru C.; Tobin, Martin D.; Elliott, Paul; Van, Duijn; Cornelia M., McEniery CM; Wilkinson, Ib; Cockcroft, Jr; O'Shaughnessy, Km; Newhouse, Sj; Yasmin, ; Smith, Av; Eiriksdottir, G; Launer, Lj; Sigurdsson, S; Aspelund, T; Gudnason, V; De Bacquer, D; Rietzschel, Er; De Backer, Gg; Van Bortel, L; De Buyzere, Ml; Segers, P; Bekaert, S; Gillebert, Tc; De Meyer, T; Ferrucci, L; Tanaka, T; Johnson, Ad; Levy, D; Benjamin, Ej; Mitchell, Gf; Vita, Ja; Larson, Mg; Hamburg, Nm; Vasan, Rs; Isaacs, A; Schut, Af; Oostra, Ba; van Duijn, Cm; van Rijn, Mj; Sie, Mp; Newman, Ab; Herrington, Dm; Andrews, Js; Ding, J; Sutton-Tyrrell, Kc; Harris, Tb; Howard, Td; Liu, Y; Parsa, A; Shuldiner, Ar; Mcardle, Pf; Gibson, Q; Post, Ws; Dehghan, A; Hofman, A; Uitterlinden, Ag; Sijbrands, Ej; Rivadeneira, F; Mattace-Raso, Fu; Verwoert, Gc; Witteman, Jc; Scuteri, A; Lakatta, Eg; Jewell, E; Abecasis, Gr; Tarasov, Kv; Uda, M; Najjar, Ss; Sanna, S; Attwood, T; Belz, S; Braund, P; Cambien, F; Cooper, J; Crisp-Hihn, A; Deloukas, P; Foad, N; Eardman, J; Goodall, Ah; Gracey, J; Gray, E; Gulde, S; Gwilliams, R; Heimerl, S; Hengstenberg, C; Jolley, J; Krishnan, U; Linsel-Nitschke, P; Lloyd-Jones, H; Lugauer, I; Lundmark, P; Maouche, S; Moore, Js; Muir, D; Murray, E; Nelson, Cp; Neudert, J; Niblett, D; O'Leary, K; Ouwehand, Wh; Pollard, H; Rankin, A; Rice, Cm; Sager, H; Samani, Nj; Sambrook, J; Schmitz, G; Scholz, M; Schroeder, L; Schunkert, H; Syvannen, Ac; Wallace, C; Kathiresan, S; Reilly, Mp; Samani, Nj; Schunkert, H; Erdmann, J; Assimes, Tl; Boerwinkle, E; Erdmann, J; Hall, A; Hengstenberg, C; Kathiresan, S; König, Ir; Laaksonen, R; Mcpherson, R; Reilly, Mp; Samani, Nj; Schunkert, H; Thompson, Jr; Thorsteinsdottir, U; Ziegler, A; 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[10.1038/ng.922]