Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations / Okada, Yukinori; Sim, Xueling; Go, Min Jin; Wu, Jer-Yuarn; Gu, Dongfeng; Takeuchi, Fumihiko; Takahashi, Atsushi; Maeda, Shiro; Tsunoda, Tatsuhiko; Chen, Peng; Lim, Su-Chi; Wong, Tien-Yin; Liu, Jianjun; Young, Terri L.; Aung, Tin; Seielstad, Mark; Teo, Yik-Ying; Kim, Young Jin; Lee, Jong-Young; Han, Bok-Ghee; Kang, Daehee; Chen, Chien-Hsiun; Tsai, Fuu-Jen; Chang, Li-Ching; Cathy Fann, S. -J. C.; Mei, Hao; Rao, Dabeeru C.; Hixson, James E.; Chen, Shufeng; Katsuya, Tomohiro; Isono, Masato; Ogihara, Toshio; Chambers, John C.; Zhang, Weihua; Kooner, Jaspal S.; Albrecht, Eva; Yamamoto, Kazuhiko; Kubo, Michiaki; Nakamura, Yusuke; Kamatani, Naoyuki; Kato, Norihiro; He, Jiang; Chen, Yuan-Tsong; Cho, Yoon Shin; Tai, E-Shyong; Tanaka, Toshihiro; Chambers, Jc; Zhang, W; Lord, Gm; van der Harst, P; Lawlor, Da; Sehmi, Js; Gale, Dp; Wass, Mn; Ahmadi, Kr; Bakker, Sj; Beckmann, J; Bilo, Hj; Bochud, M; Brown, Mj; Caulfield, Mj; Connell, Jm; Cook, Ht; Cotlarciuc, I; Smith, Gd; de Silva, R Deng G; Devuyst, O; Dikkeschei, Ld; Dimkovic, N; Dockrell, M; Dominiczak, A; Ebrahim, S; Eggermann, T; Farrall, M; Ferrucci, L; Floege, J; Forouhi, Ng; Gansevoort, Rt; Han, X; Hedblad, B; van der Heide, Jj; Hepkema, Bg; Hernandez-Fuentes, M; Hypponen, E; Johnson, T; de Jong, Pe; Kleefstra, N; Lagou, V; Lapsley, M; Li, Y; Loos, Rj; Luan, J; Luttropp, K; Maréchal, C; Melander, O; Munroe, Pb; Nordfors, L; Parsa, A; Peltonen, L; Penninx, Bw; Perucha, E; Pouta, A; Prokopenko, I; Roderick, Pj; Ruokonen, A; Samani, Nj; Sanna, S; Schalling, M; Schlessinger, D; Schlieper, G; Seelen, Ma; Shuldiner, Ar; Sjögren, M; Smit, Jh; Snieder, H; Soranzo, N; Spector, Td; Stenvinkel, P; Sternberg, Mj; Swaminathan, R; Tanaka, T; Ubink-Veltmaat, Lj; Uda, M; Vollenweider, P; Wallace, C; Waterworth, D; Zerres, K; Waeber, G; Wareham, Nj; Maxwell, Ph; Mccarthy, Mi; Jarvelin, Mr; Mooser, V; Abecasis, Gr; Lightstone, L; Scott, J; Navis, G; Elliott, P; Kooner, Js; Köttgen, A; Pattaro, C; Böger, Ca; Fuchsberger, C; Olden, M; Glazer, Nl; Parsa, A; Gao, X; Yang, Q; Smith, Av; O'Connell, Jr; Li, M; Schmidt, H; Tanaka, T; Isaacs, A; Ketkar, S; Hwang, Sj; Johnson, Ad; Dehghan, A; Teumer, A; Paré, G; Atkinson, Ej; Zeller, T; Lohman, K; Cornelis, Mc; Probst-Hensch, Nm; Kronenberg, F; Tönjes, A; Hayward, C; Aspelund, T; Eiriksdottir, G; Launer, Lj; Harris, Tb; Rampersaud, E; Mitchell, Bd; Arking, De; Boerwinkle, E; Struchalin, M; Cavalieri, M; Singleton, A; Giallauria, Francesco; Metter, J; de Boer, Ih; Haritunians, T; Lumley, T; Siscovick, D; Psaty, Bm; Zillikens, Mc; Oostra, Ba; Feitosa, M; Province, M; de Andrade, M; Turner, St; Schillert, A; Ziegler, A; Wild, Ps; Schnabel, Rb; Wilde, S; Munzel, Tf; Leak, Ts; Illig, T; Klopp, N; Meisinger, C; Wichmann, He; Koenig, W; Zgaga, L; Zemunik, T; Kolcic, I; Minelli, C; Hu, Fb; Johansson, Å; Igl, W; Zaboli, G; Wild, Sh; Wright, Af; Campbell, H; Ellinghaus, D; Schreiber, S; Aulchenko, Ys; Felix, Jf; Rivadeneira, F; Uitterlinden, Ag; Hofman, A; Imboden, M; Nitsch, D; Brandstätter, A; Kollerits, B; Kedenko, L; Mägi, R; Stumvoll, M; Kovacs, P; Boban, M; Campbell, S; Endlich, K; Völzke, H; Kroemer, Hk; Nauck, M; Völker, U; Polasek, O; Vitart, V; Badola, S; Parker, An; Ridker, Pm; Kardia, Sl; Blankenberg, S; Liu, Y; Curhan, Gc; Franke, A; Rochat, T; Paulweber, B; Prokopenko, I; Wang, W; Gudnason, V; Shuldiner, Ar; Coresh, J; Schmidt, R; Ferrucci, L; Shlipak, Mg; van Duijn, Cm; Borecki, I; Krämer, Bk; Rudan, I; Gyllensten, U; Wilson, Jf; Witteman, Jc; Pramstaller, Pp; Rettig, R; Hastie, N; Chasman, Di; Kao, Wh; Heid, Im; Fox, Cs; Köttgen, A; Albrecht, E; Teumer, A; Vitart, V; Krumsiek, J; Hundertmark, C; Pistis, G; Ruggiero, D; O'Seaghdha, M; Haller, T; Yang, Q; Tanaka, T; Johnson, Ad; Kutalik, Z; Smith, Av; Shi, J; Struchalin, M; Middelberg, Ps; Brown, Mj; Gaffo, Al; Pirastu, N; Li, G; Hayward, C; Zemunik, T; Huffman, J; Yengo, L; Zhao, Jh; Demirkan, A; Feitosa, Mf; Liu, X; Malerba, G; Lopez, Lm; van der Harst, P; Li, X; Kleber, Me; Hicks, Aa; Nolte, Im; Johansson, A; Murgia, F; Wild, Sh; Bakker, Sj; Peden, Jf; Dehghan, A; Steri, M; Tenesa, A; Lagou, V; Salo, P; Mangino, M; Rose, Lm; Lehtimäki, T; Woodward, Om; Okada, Y; Tin, A; Müller, C; Oldmeadow, C; Putku, M; Czamara, D; Kraft, P; Frogheri, L; Thun, Ga; Grotevendt, A; Gislason, Gk; Harris, Tb; Launer, Lj; Mcardle, P; Shuldiner, Ar; Boerwinkle, E; Coresh, J; Schmidt, H; Schallert, M; Martin, Ng; Montgomery, Gw; Kubo, M; Nakamura, Y; Tanaka, T; Munroe, Pb; Samani, Nj; Jacobs DR, Jr; Liu, K; D'Adamo, P; Ulivi, S; Rotter, Ji; Psaty, Bm; Vollenweider, P; Waeber, G; Campbell, S; Devuyst, O; Navaro, P; Kolcic, I; Hastie, N; Balkau, B; Froguel, P; Esko, T; Salumets, A; Khaw, Kt; Langenberg, C; Wareham, Nj; Isaacs, A; Kraja, A; Zhang, Q; Wild, Ps; Scott, Rj; Holliday, Eg; Org, E; Viigimaa, M; Bandinelli, S; Metter, Je; Lupo, A; Trabetti, E; Sorice, R; Döring, A; Lattka, E; Strauch, K; Theis, F; Waldenberger, M; Wichmann, He; Davies, G; Gow, Aj; Bruinenberg, M; Stolk, Rp; Kooner, Js; Zhang, W; Winkelmann, Br; Boehm, Bo; Lucae, S; Penninx, Bw; Smit, Jh; Curhan, G; Mudgal, P; Plenge, Rm; Portas, L; Persico, I; Kirin, M; Wilson, Jf; Mateo Leach, I; van Gilst, Wh; Goel, A; Ongen, H; Hofman, A; Rivadeneira, F; Uitterlinden, Ag; Imboden, M; von Eckardstein, A; Cucca, F; Nagaraja, R; Piras, Mg; Nauck, M; Schurmann, C; Budde, K; Ernst, F; Farrington, Sm; Theodoratou, E; Prokopenko, I; Stumvoll, M; Jula, A; Perola, M; Salomaa, V; Shin, Sy; Spector, Td; Sala, C; Ridker, Pm; Kähönen, M; Viikari, J; Hengstenberg, C; Nelson, Cp; Meschia, Jf; Nalls, Ma; Sharma, P; Singleton, Ab; Kamatani, N; Zeller, T; Burnier, M; Attia, J; Laan, M; Klopp, N; Hillege, Hl; Kloiber, S; Choi, H; Pirastu, M; Tore, S; Probst-Hensch, Nm; Völzke, H; Gudnason, V; Parsa, A; Schmidt, R; Whitfield, Jb; Fornage, M; Gasparini, P; Siscovick, Ds; Polasek, O; Campbell, H; Rudan, I; Bouatia-Naji, N; Metspalu, A; Loos, Rj; van Duijn, Cm; Borecki, Ib; Ferrucci, L; Gambaro, G; Deary, Ij; Wolffenbuttel, Bh; Chambers, Jc; März, W; Pramstaller, Pp; Snieder, H; Gyllensten, U; Wright, Af; Navis, G; Watkins, H; Witteman, Jc; Sanna, S; Schipf, S; Dunlop, Mg; Tönjes, A; Ripatti, S; Soranzo, N; Toniolo, D; Chasman, Di; Raitakari, O; Kao, Wh; Ciullo, M; Fox, Cs; Caulfield, M; Bochud, M; Gieger, C.. - In: NATURE GENETICS. - ISSN 1061-4036. - 44:8(2012), pp. 904-909. [10.1038/ng.2352]
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations
Okada, Yukinori; Sim, Xueling; Go, Min Jin; Wu, Jer-Yuarn; Gu, Dongfeng; Takeuchi, Fumihiko; Takahashi, Atsushi; Maeda, Shiro; Tsunoda, Tatsuhiko; Chen, Peng; Lim, Su-Chi; Wong, Tien-Yin; Liu, Jianjun; Young, Terri L.; Aung, Tin; Seielstad, Mark; Teo, Yik-Ying; Kim, Young Jin; Lee, Jong-Young; Han, Bok-Ghee; Kang, Daehee; Chen, Chien-Hsiun; Tsai, Fuu-Jen; Chang, Li-Ching; Cathy Fann, S. -J. C.; Mei, Hao; Rao, Dabeeru C.; Hixson, James E.; Chen, Shufeng; Katsuya, Tomohiro; Isono, Masato; Ogihara, Toshio; Chambers, John C.; Zhang, Weihua; Kooner, Jaspal S.; Albrecht, Eva; Yamamoto, Kazuhiko; Kubo, Michiaki; Nakamura, Yusuke; Kamatani, Naoyuki; Kato, Norihiro; He, Jiang; Chen, Yuan-Tsong; Cho, Yoon Shin; Tai, E-Shyong; Tanaka, Toshihiro; Chambers JC; Zhang W; Lord GM; van der Harst P; Lawlor DA; Sehmi JS; Gale DP; Wass MN; Ahmadi KR; Bakker SJ; Beckmann J; Bilo HJ; Bochud M; Brown MJ; Caulfield MJ; Connell JM; Cook HT; Cotlarciuc I; Smith GD; de Silva R Deng G; Devuyst O; Dikkeschei LD; Dimkovic N; Dockrell M; Dominiczak A; Ebrahim S; Eggermann T; Farrall M; Ferrucci L; Floege J; Forouhi NG; Gansevoort RT; Han X; Hedblad B; van der Heide JJ; Hepkema BG; Hernandez-Fuentes M; Hypponen E; Johnson T; de Jong PE; Kleefstra N; Lagou V; Lapsley M; Li Y; Loos RJ; Luan J; Luttropp K; Maréchal C; Melander O; Munroe PB; Nordfors L; Parsa A; Peltonen L; Penninx BW; Perucha E; Pouta A; Prokopenko I; Roderick PJ; Ruokonen A; Samani NJ; Sanna S; Schalling M; Schlessinger D; Schlieper G; Seelen MA; Shuldiner AR; Sjögren M; Smit JH; Snieder H; Soranzo N; Spector TD; Stenvinkel P; Sternberg MJ; Swaminathan R; Tanaka T; Ubink-Veltmaat LJ; Uda M; Vollenweider P; Wallace C; Waterworth D; Zerres K; Waeber G; Wareham NJ; Maxwell PH; McCarthy MI; Jarvelin MR; Mooser V; Abecasis GR; Lightstone L; Scott J; Navis G; Elliott P; Kooner JS; Köttgen A; Pattaro C; Böger CA; Fuchsberger C; Olden M; Glazer NL; Parsa A; Gao X; Yang Q; Smith AV; O'Connell JR; Li M; Schmidt H; Tanaka T; Isaacs A; Ketkar S; Hwang SJ; Johnson AD; Dehghan A; Teumer A; Paré G; Atkinson EJ; Zeller T; Lohman K; Cornelis MC; Probst-Hensch NM; Kronenberg F; Tönjes A; Hayward C; Aspelund T; Eiriksdottir G; Launer LJ; Harris TB; Rampersaud E; Mitchell BD; Arking DE; Boerwinkle E; Struchalin M; Cavalieri M; Singleton A; Giallauria, Francesco ;Metter J; de Boer IH; Haritunians T; Lumley T; Siscovick D; Psaty BM; Zillikens MC; Oostra BA; Feitosa M; Province M; de Andrade M; Turner ST; Schillert A; Ziegler A; Wild PS; Schnabel RB; Wilde S; Munzel TF; Leak TS; Illig T; Klopp N; Meisinger C; Wichmann HE; Koenig W; Zgaga L; Zemunik T; Kolcic I; Minelli C; Hu FB; Johansson Å; Igl W; Zaboli G; Wild SH; Wright AF; Campbell H; Ellinghaus D; Schreiber S; Aulchenko YS; Felix JF; Rivadeneira F; Uitterlinden AG; Hofman A; Imboden M; Nitsch D; Brandstätter A; Kollerits B; Kedenko L; Mägi R; Stumvoll M; Kovacs P; Boban M; Campbell S; Endlich K; Völzke H; Kroemer HK; Nauck M; Völker U; Polasek O; Vitart V; Badola S; Parker AN; Ridker PM; Kardia SL; Blankenberg S; Liu Y; Curhan GC; Franke A; Rochat T; Paulweber B; Prokopenko I; Wang W; Gudnason V; Shuldiner AR; Coresh J; Schmidt R; Ferrucci L; Shlipak MG; van Duijn CM; Borecki I; Krämer BK; Rudan I; Gyllensten U; Wilson JF; Witteman JC; Pramstaller PP; Rettig R; Hastie N; Chasman DI; Kao WH; Heid IM; Fox CS; Köttgen A; Albrecht E; Teumer A; Vitart V; Krumsiek J; Hundertmark C; Pistis G; Ruggiero D; O'Seaghdha M; Haller T; Yang Q; Tanaka T; Johnson AD; Kutalik Z; Smith AV; Shi J; Struchalin M; Middelberg PS; Brown MJ; Gaffo AL; Pirastu N; Li G; Hayward C; Zemunik T; Huffman J; Yengo L; Zhao JH; Demirkan A; Feitosa MF; Liu X; Malerba G; Lopez LM; van der Harst P; Li X; Kleber ME; Hicks AA; Nolte IM; Johansson A; Murgia F; Wild SH; Bakker SJ; Peden JF; Dehghan A; Steri M; Tenesa A; Lagou V; Salo P; Mangino M; Rose LM; Lehtimäki T; Woodward OM; Okada Y; Tin A; Müller C; Oldmeadow C; Putku M; Czamara D; Kraft P; Frogheri L; Thun GA; Grotevendt A; Gislason GK; Harris TB; Launer LJ; McArdle P; Shuldiner AR; Boerwinkle E; Coresh J; Schmidt H; Schallert M; Martin NG; Montgomery GW; Kubo M; Nakamura Y; Tanaka T; Munroe PB; Samani NJ; Jacobs DR Jr; Liu K; D'Adamo P; Ulivi S; Rotter JI; Psaty BM; Vollenweider P; Waeber G; Campbell S; Devuyst O; Navaro P; Kolcic I; Hastie N; Balkau B; Froguel P; Esko T; Salumets A; Khaw KT; Langenberg C; Wareham NJ; Isaacs A; Kraja A; Zhang Q; Wild PS; Scott RJ; Holliday EG; Org E; Viigimaa M; Bandinelli S; Metter JE; Lupo A; Trabetti E; Sorice R; Döring A; Lattka E; Strauch K; Theis F; Waldenberger M; Wichmann HE; Davies G; Gow AJ; Bruinenberg M; Stolk RP; Kooner JS; Zhang W; Winkelmann BR; Boehm BO; Lucae S; Penninx BW; Smit JH; Curhan G; Mudgal P; Plenge RM; Portas L; Persico I; Kirin M; Wilson JF; Mateo Leach I; van Gilst WH; Goel A; Ongen H; Hofman A; Rivadeneira F; Uitterlinden AG; Imboden M; von Eckardstein A; Cucca F; Nagaraja R; Piras MG; Nauck M; Schurmann C; Budde K; Ernst F; Farrington SM; Theodoratou E; Prokopenko I; Stumvoll M; Jula A; Perola M; Salomaa V; Shin SY; Spector TD; Sala C; Ridker PM; Kähönen M; Viikari J; Hengstenberg C; Nelson CP; Meschia JF; Nalls MA; Sharma P; Singleton AB; Kamatani N; Zeller T; Burnier M; Attia J; Laan M; Klopp N; Hillege HL; Kloiber S; Choi H; Pirastu M; Tore S; Probst-Hensch NM; Völzke H; Gudnason V; Parsa A; Schmidt R; Whitfield JB; Fornage M; Gasparini P; Siscovick DS; Polasek O; Campbell H; Rudan I; Bouatia-Naji N; Metspalu A; Loos RJ; van Duijn CM; Borecki IB; Ferrucci L; Gambaro G; Deary IJ; Wolffenbuttel BH; Chambers JC; März W; Pramstaller PP; Snieder H; Gyllensten U; Wright AF; Navis G; Watkins H; Witteman JC; Sanna S; Schipf S; Dunlop MG; Tönjes A; Ripatti S; Soranzo N; Toniolo D; Chasman DI; Raitakari O; Kao WH; Ciullo M; Fox CS; Caulfield M; Bochud M; Gieger C.
2012
Abstract
Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.
Citazione
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations / Okada, Yukinori; Sim, Xueling; Go, Min Jin; Wu, Jer-Yuarn; Gu, Dongfeng; Takeuchi, Fumihiko; Takahashi, Atsushi; Maeda, Shiro; Tsunoda, Tatsuhiko; Chen, Peng; Lim, Su-Chi; Wong, Tien-Yin; Liu, Jianjun; Young, Terri L.; Aung, Tin; Seielstad, Mark; Teo, Yik-Ying; Kim, Young Jin; Lee, Jong-Young; Han, Bok-Ghee; Kang, Daehee; Chen, Chien-Hsiun; Tsai, Fuu-Jen; Chang, Li-Ching; Cathy Fann, S. -J. C.; Mei, Hao; Rao, Dabeeru C.; Hixson, James E.; Chen, Shufeng; Katsuya, Tomohiro; Isono, Masato; Ogihara, Toshio; Chambers, John C.; Zhang, Weihua; Kooner, Jaspal S.; Albrecht, Eva; Yamamoto, Kazuhiko; Kubo, Michiaki; Nakamura, Yusuke; Kamatani, Naoyuki; Kato, Norihiro; He, Jiang; Chen, Yuan-Tsong; Cho, Yoon Shin; Tai, E-Shyong; Tanaka, Toshihiro; Chambers, Jc; Zhang, W; Lord, Gm; van der Harst, P; Lawlor, Da; Sehmi, Js; Gale, Dp; Wass, Mn; Ahmadi, Kr; Bakker, Sj; Beckmann, J; Bilo, Hj; Bochud, M; Brown, Mj; Caulfield, Mj; Connell, Jm; Cook, Ht; Cotlarciuc, I; Smith, Gd; de Silva, R Deng G; Devuyst, O; Dikkeschei, Ld; Dimkovic, N; Dockrell, M; Dominiczak, A; Ebrahim, S; Eggermann, T; Farrall, M; Ferrucci, L; Floege, J; Forouhi, Ng; Gansevoort, Rt; Han, X; Hedblad, B; van der Heide, Jj; Hepkema, Bg; Hernandez-Fuentes, M; Hypponen, E; Johnson, T; de Jong, Pe; Kleefstra, N; Lagou, V; Lapsley, M; Li, Y; Loos, Rj; Luan, J; Luttropp, K; Maréchal, C; Melander, O; Munroe, Pb; Nordfors, L; Parsa, A; Peltonen, L; Penninx, Bw; Perucha, E; Pouta, A; Prokopenko, I; Roderick, Pj; Ruokonen, A; Samani, Nj; Sanna, S; Schalling, M; Schlessinger, D; Schlieper, G; Seelen, Ma; Shuldiner, Ar; Sjögren, M; Smit, Jh; Snieder, H; Soranzo, N; Spector, Td; Stenvinkel, P; Sternberg, Mj; Swaminathan, R; Tanaka, T; Ubink-Veltmaat, Lj; Uda, M; Vollenweider, P; Wallace, C; Waterworth, D; Zerres, K; Waeber, G; Wareham, Nj; Maxwell, Ph; Mccarthy, Mi; Jarvelin, Mr; Mooser, V; Abecasis, Gr; Lightstone, L; Scott, J; Navis, G; Elliott, P; Kooner, Js; Köttgen, A; Pattaro, C; Böger, Ca; Fuchsberger, C; Olden, M; Glazer, Nl; Parsa, A; Gao, X; Yang, Q; Smith, Av; O'Connell, Jr; Li, M; Schmidt, H; Tanaka, T; Isaacs, A; Ketkar, S; Hwang, Sj; Johnson, Ad; Dehghan, A; Teumer, A; Paré, G; Atkinson, Ej; Zeller, T; Lohman, K; Cornelis, Mc; Probst-Hensch, Nm; Kronenberg, F; Tönjes, A; Hayward, C; Aspelund, T; Eiriksdottir, G; Launer, Lj; Harris, Tb; Rampersaud, E; Mitchell, Bd; Arking, De; Boerwinkle, E; Struchalin, M; Cavalieri, M; Singleton, A; Giallauria, Francesco; Metter, J; de Boer, Ih; Haritunians, T; Lumley, T; Siscovick, D; Psaty, Bm; Zillikens, Mc; Oostra, Ba; Feitosa, M; Province, M; de Andrade, M; Turner, St; Schillert, A; Ziegler, A; Wild, Ps; Schnabel, Rb; Wilde, S; Munzel, Tf; Leak, Ts; Illig, T; Klopp, N; Meisinger, C; Wichmann, He; Koenig, W; Zgaga, L; Zemunik, T; Kolcic, I; Minelli, C; Hu, Fb; Johansson, Å; Igl, W; Zaboli, G; Wild, Sh; Wright, Af; Campbell, H; Ellinghaus, D; Schreiber, S; Aulchenko, Ys; Felix, Jf; Rivadeneira, F; Uitterlinden, Ag; Hofman, A; Imboden, M; Nitsch, D; Brandstätter, A; Kollerits, B; Kedenko, L; Mägi, R; Stumvoll, M; Kovacs, P; Boban, M; Campbell, S; Endlich, K; Völzke, H; Kroemer, Hk; Nauck, M; Völker, U; Polasek, O; Vitart, V; Badola, S; Parker, An; Ridker, Pm; Kardia, Sl; Blankenberg, S; Liu, Y; Curhan, Gc; Franke, A; Rochat, T; Paulweber, B; Prokopenko, I; Wang, W; Gudnason, V; Shuldiner, Ar; Coresh, J; Schmidt, R; Ferrucci, L; Shlipak, Mg; van Duijn, Cm; Borecki, I; Krämer, Bk; Rudan, I; Gyllensten, U; Wilson, Jf; Witteman, Jc; Pramstaller, Pp; Rettig, R; Hastie, N; Chasman, Di; Kao, Wh; Heid, Im; Fox, Cs; Köttgen, A; Albrecht, E; Teumer, A; Vitart, V; Krumsiek, J; Hundertmark, C; Pistis, G; Ruggiero, D; O'Seaghdha, M; Haller, T; Yang, Q; Tanaka, T; Johnson, Ad; Kutalik, Z; Smith, Av; Shi, J; Struchalin, M; Middelberg, Ps; Brown, Mj; Gaffo, Al; Pirastu, N; Li, G; Hayward, C; Zemunik, T; Huffman, J; Yengo, L; Zhao, Jh; Demirkan, A; Feitosa, Mf; Liu, X; Malerba, G; Lopez, Lm; van der Harst, P; Li, X; Kleber, Me; Hicks, Aa; Nolte, Im; Johansson, A; Murgia, F; Wild, Sh; Bakker, Sj; Peden, Jf; Dehghan, A; Steri, M; Tenesa, A; Lagou, V; Salo, P; Mangino, M; Rose, Lm; Lehtimäki, T; Woodward, Om; Okada, Y; Tin, A; Müller, C; Oldmeadow, C; Putku, M; Czamara, D; Kraft, P; Frogheri, L; Thun, Ga; Grotevendt, A; Gislason, Gk; Harris, Tb; Launer, Lj; Mcardle, P; Shuldiner, Ar; Boerwinkle, E; Coresh, J; Schmidt, H; Schallert, M; Martin, Ng; Montgomery, Gw; Kubo, M; 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[10.1038/ng.2352]
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Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande. La presente simulazione è stata realizzata sulla base delle specifiche raccolte sul tavolo ER del Focus Group IRIS coordinato dall’Università di Modena e Reggio Emilia e delle regole riportate nel DM 589/2018 e allegata Tabella A. Cineca, l’Università di Modena e Reggio Emilia e il Focus Group IRIS non si assumono alcuna responsabilità in merito all’uso che il diretto interessato o terzi faranno della simulazione. Si specifica inoltre che la simulazione contiene calcoli effettuati con dati e algoritmi di pubblico dominio e deve quindi essere considerata come un mero ausilio al calcolo svolgibile manualmente o con strumenti equivalenti.