Lactobacillus gassers SF1183 protects the intestinal epithelium and prevents colitis symptoms in vivo

Di Luccia, B; Mazzoli, A; DI LUCCIA AND MAZZOLI: FIRST COAUTHORSHIP,; Cancelliere, R; Crescenzo, R; Ferrandino, I; Monaco, A; Bucci, A; Naclerio, G; Iossa, S; Ricca, E; Baccigalupi, L

doi:10.1016/j.jff.2017.12.049

Lactobacillus gasseri SF1183 belongs to a subpopulation of bacteria tightly associated to the human ileal epithelium. Cells of SF1183 survive and grow in simulated intestinal and gastric conditions, have a strong antimicrobial activity against Gram-positives and Gram-negatives and secrete molecule(s) sensed by human intestinal cells. We report that the oral administration of SF1183 cells had a protective effect in a murine model of DSS (Dextran-Sulfate-Sodium)-induced colitis. The analysis of the intestinal microbial composition indicated that several bacterial genera were differently represented in the intestine of DSS-treated animals. An overall similar alteration was observed in the microbiota of DSS-treated animals that received SF1183, suggesting that the beneficial role of the probiotic was not played through a reshuffling of the intestinal flora. Based on our in vivo data we propose the SF1183 strain of L. gasseri as a new anti-inflammatory probiotic, potentially useful as a therapeutic agent for the treatment of IBDs.

Lactobacillus gassers SF1183 protects the intestinal epithelium and prevents colitis symptoms in vivo / Di Luccia, B; Mazzoli, A; DI LUCCIA AND MAZZOLI: FIRST, Coauthorship; Cancelliere, R; Crescenzo, R; Ferrandino, I; Monaco, A; Bucci, A; Naclerio, G; Iossa, S; Ricca, E; Baccigalupi, L. - In: JOURNAL OF FUNCTIONAL FOODS. - ISSN 1756-4646. - 42:(2018), pp. 195-202. [10.1016/j.jff.2017.12.049]