Protontherapy is hadrontherapy's fastest-growing modality and a pillar in the battle against cancer. Hadrontherapy's superiority lies in its inverted depth-dose profile, hence tumour-confined irradiation. Protons, however, lack distinct radiobiological advantages over photons or electrons. Higher LET ( Linear Energy Transfer) C-12-ions can overcome cancer radioresistance: DNA lesion complexity increases with LET, resulting in efficient cell killing, i.e. higher Relative Biological Effectiveness (RBE). However, economic and radiobiological issues hamper C-12-ion clinical amenability. Thus, enhancing proton RBE is desirable. To this end, we exploited the p + B-11 -> 3 alpha reaction to generate high-LET alpha particles with a clinical proton beam. To maximize the reaction rate, we used sodium borocaptate (BSH) with natural boron content. Boron-Neutron Capture Therapy (BNCT) uses B-10-enriched BSH for neutron irradiationtriggered alpha particles. We recorded significantly increased cellular lethality and chromosome aberration complexity. A strategy combining protontherapy's ballistic precision with the higher RBE promised by BNCT and C-12-ion therapy is thus demonstrated.

First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness / Cirrone, G. A. P.; Manti, L.; Margarone, D.; Petringa, G.; Giuffrida, L.; Minopoli, A.; Picciotto, A.; Russo, G.; Cammarata, F.; Pisciotta, P.; Perozziello, F. M.; Romano, F.; Marchese, V.; Milluzzo, G.; Scuderi, V.; Cuttone, G.; Korn, G.. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 8:1(2018), p. 1141. [10.1038/s41598-018-19258-5]

First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness

Manti, L.
Writing – Original Draft Preparation
;
Perozziello, F. M.;
2018

Abstract

Protontherapy is hadrontherapy's fastest-growing modality and a pillar in the battle against cancer. Hadrontherapy's superiority lies in its inverted depth-dose profile, hence tumour-confined irradiation. Protons, however, lack distinct radiobiological advantages over photons or electrons. Higher LET ( Linear Energy Transfer) C-12-ions can overcome cancer radioresistance: DNA lesion complexity increases with LET, resulting in efficient cell killing, i.e. higher Relative Biological Effectiveness (RBE). However, economic and radiobiological issues hamper C-12-ion clinical amenability. Thus, enhancing proton RBE is desirable. To this end, we exploited the p + B-11 -> 3 alpha reaction to generate high-LET alpha particles with a clinical proton beam. To maximize the reaction rate, we used sodium borocaptate (BSH) with natural boron content. Boron-Neutron Capture Therapy (BNCT) uses B-10-enriched BSH for neutron irradiationtriggered alpha particles. We recorded significantly increased cellular lethality and chromosome aberration complexity. A strategy combining protontherapy's ballistic precision with the higher RBE promised by BNCT and C-12-ion therapy is thus demonstrated.
2018
First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness / Cirrone, G. A. P.; Manti, L.; Margarone, D.; Petringa, G.; Giuffrida, L.; Minopoli, A.; Picciotto, A.; Russo, G.; Cammarata, F.; Pisciotta, P.; Perozziello, F. M.; Romano, F.; Marchese, V.; Milluzzo, G.; Scuderi, V.; Cuttone, G.; Korn, G.. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 8:1(2018), p. 1141. [10.1038/s41598-018-19258-5]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/700368
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