The presence of macrophages and their activation on the pulmonary tissues of 21 subjects deceased after CO intoxication has been studied. A notable number of activated macrophages, especially in the interstitial level, have been evidenced, and such phenomenon supports the hypothesis of a possible association between CO intoxication and pulmonary macrophages activity. The highlighted association could be mediated by changes of the surfactant, by impairing of mitochondrial respiration and by release of pro-inflammatory cytokines.
Pulmonary macrophages activity in CO intoxication / Pieri, Maria; Giugliano, Pasquale; Vacchiano, Giuseppe. - In: JOURNAL OF FORENSIC AND LEGAL MEDICINE. - ISSN 1752-928X. - 38:(2016), p. 93-6. [10.1016/j.jflm.2015.12.002]
Pulmonary macrophages activity in CO intoxication
PIERI, MARIA;GIUGLIANO, Pasquale;VACCHIANO, GIUSEPPE
2016
Abstract
The presence of macrophages and their activation on the pulmonary tissues of 21 subjects deceased after CO intoxication has been studied. A notable number of activated macrophages, especially in the interstitial level, have been evidenced, and such phenomenon supports the hypothesis of a possible association between CO intoxication and pulmonary macrophages activity. The highlighted association could be mediated by changes of the surfactant, by impairing of mitochondrial respiration and by release of pro-inflammatory cytokines.| File | Dimensione | Formato | |
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