OBJECTIVE: To evaluate the risk of preeclampsia in pregnant women with human immunodeficiency virus (HIV). METHODS: This is a 26-year population-based retrospective cohort study. Human immunodeficiency virus-infected pregnant women were compared with a HIV-negative comparison group. The primary outcome was the incidence of preeclampsia. We planned subgroup analysis according to antiretroviral therapy. RESULTS: A total of 84,725 women were included in the analysis, of whom 453 were HIV-infected and 84,272 HIV-negative. Of the 453 HIV-infected women, 301 (66.4%) received highly active antiretroviral therapy (HAART group) during pregnancy, whereas 152 (33.6%) did not. After adjusting for confounders, we found that HIV-infected women had a significantly higher risk of preeclampsia (10.2% compared with 4.1%; adjusted odds ratio [OR] 2.68, 95% confidence interval [CI] 1.96-3.64), preeclampsia with severe features (4.0% compared with 2.0%; adjusted OR 2.03, 95% CI 1.26-3.28), early-onset (3.5% compared with 1.4%; adjusted OR 2.50, 95% CI 1.51-4.15) and late-onset preeclampsia (6.6% compared with 2.6%; adjusted OR 2.64, 95% CI 1.82-3.85), and preterm birth at less than 37 weeks of gestation (11.0% compared with 4.7%; adjusted OR 2.50, 95% CI 1.86-3.37) compared with the comparison group. Human immunodeficiency virus-infected women who received HAART had a significantly higher risk of preeclampsia compared with women without HIV (13.0% compared with 4.1%; adjusted OR 3.52, 95% CI 2.51-4.94) and compared with the non-HAART group (13.0% compared with 4.6%; adjusted OR 3.08, 95% CI 1.34-5.07). The non-HAART group had a similar risk compared with women without HIV (4.6% compared with 4.1%; adjusted OR 1.14, 95% CI 0.53-2.44). CONCLUSION: Human immunodeficiency virus-infected women had an increased risk of preeclampsia. Some of this risk seems to be linked to HAART.

Risk of preeclampsia in human immunodeficiency virus-infected pregnant women / Sansone, M.; Sarno, L.; Saccone, G.; Berghella, V.; Maruotti, G. M.; Migliucci, A.; Capone, A.; Martinelli, P.. - In: OBSTETRICS AND GYNECOLOGY. - ISSN 0029-7844. - 127:6(2016), pp. 1027-1032. [10.1097/AOG.0000000000001424]

Risk of preeclampsia in human immunodeficiency virus-infected pregnant women

L. Sarno;G. Saccone;G. M. Maruotti;A. Migliucci;A. Capone;P. Martinelli
2016

Abstract

OBJECTIVE: To evaluate the risk of preeclampsia in pregnant women with human immunodeficiency virus (HIV). METHODS: This is a 26-year population-based retrospective cohort study. Human immunodeficiency virus-infected pregnant women were compared with a HIV-negative comparison group. The primary outcome was the incidence of preeclampsia. We planned subgroup analysis according to antiretroviral therapy. RESULTS: A total of 84,725 women were included in the analysis, of whom 453 were HIV-infected and 84,272 HIV-negative. Of the 453 HIV-infected women, 301 (66.4%) received highly active antiretroviral therapy (HAART group) during pregnancy, whereas 152 (33.6%) did not. After adjusting for confounders, we found that HIV-infected women had a significantly higher risk of preeclampsia (10.2% compared with 4.1%; adjusted odds ratio [OR] 2.68, 95% confidence interval [CI] 1.96-3.64), preeclampsia with severe features (4.0% compared with 2.0%; adjusted OR 2.03, 95% CI 1.26-3.28), early-onset (3.5% compared with 1.4%; adjusted OR 2.50, 95% CI 1.51-4.15) and late-onset preeclampsia (6.6% compared with 2.6%; adjusted OR 2.64, 95% CI 1.82-3.85), and preterm birth at less than 37 weeks of gestation (11.0% compared with 4.7%; adjusted OR 2.50, 95% CI 1.86-3.37) compared with the comparison group. Human immunodeficiency virus-infected women who received HAART had a significantly higher risk of preeclampsia compared with women without HIV (13.0% compared with 4.1%; adjusted OR 3.52, 95% CI 2.51-4.94) and compared with the non-HAART group (13.0% compared with 4.6%; adjusted OR 3.08, 95% CI 1.34-5.07). The non-HAART group had a similar risk compared with women without HIV (4.6% compared with 4.1%; adjusted OR 1.14, 95% CI 0.53-2.44). CONCLUSION: Human immunodeficiency virus-infected women had an increased risk of preeclampsia. Some of this risk seems to be linked to HAART.
2016
Risk of preeclampsia in human immunodeficiency virus-infected pregnant women / Sansone, M.; Sarno, L.; Saccone, G.; Berghella, V.; Maruotti, G. M.; Migliucci, A.; Capone, A.; Martinelli, P.. - In: OBSTETRICS AND GYNECOLOGY. - ISSN 0029-7844. - 127:6(2016), pp. 1027-1032. [10.1097/AOG.0000000000001424]
File in questo prodotto:
File Dimensione Formato  
36 HIV preeclampsia - Green - Sansone.pdf

accesso aperto

Descrizione: Articolo principale
Tipologia: Documento in Post-print
Licenza: Accesso privato/ristretto
Dimensione 472.04 kB
Formato Adobe PDF
472.04 kB Adobe PDF Visualizza/Apri
sansone2016.pdf

solo utenti autorizzati

Descrizione: Risk of Preeclampsia in Human Immunodeficiency Virus-Infected Pregnant Women
Tipologia: Documento in Post-print
Licenza: Accesso privato/ristretto
Dimensione 316.22 kB
Formato Adobe PDF
316.22 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
sansone2016.pdf

solo utenti autorizzati

Descrizione: Risk of Preeclampsia in Human Immunodeficiency Virus-Infected Pregnant Women
Tipologia: Documento in Post-print
Licenza: Accesso privato/ristretto
Dimensione 316.22 kB
Formato Adobe PDF
316.22 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/697894
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 44
  • ???jsp.display-item.citation.isi??? 42
social impact