Testicular germ cell tumors (TGCTs) represent the most common solid tumors affecting young men. They constitute a distinct entity because of their embryonic origin and their unique biological behavior. Recent preclinical data regarding biological signaling machinery as well as genetic and epigenetic mechanisms associated with molecular patterns of tumors have contribute to explain the pathogenesis and the differentiation of TGCTs and to understand the mechanisms responsible for the development of resistance to treatment. In this review, we discuss the main genetic and epigenetic events associated with TGCTs development in order to better define their role in the pathogenesis of these tumors and in cisplatin-acquired resistance.

Exploring the molecular aspects associated with testicular germ cell tumors: A review / Facchini, Gaetano; Rossetti, Sabrina; Cavaliere, Carla; D'Aniello, Carmine; DE FRANCO, Rossella; Iovane, Gelsomina; Grimaldi, Giovanni; Piscitelli, Raffaele; Muto, Paolo; Botti, Gerardo; Perdonà, Sisto; Veneziani, Bianca Maria; Berretta, Massimiliano; Montanari, Micaela. - In: ONCOTARGET. - ISSN 1949-2553. - 9:1(2018), pp. 1365-1379. [10.18632/oncotarget.22373]

Exploring the molecular aspects associated with testicular germ cell tumors: A review

Cavaliere, Carla;D'Aniello, Carmine;DE FRANCO, ROSSELLA;Grimaldi, Giovanni;Muto, Paolo;Veneziani, Bianca Maria;Montanari, Micaela
2018

Abstract

Testicular germ cell tumors (TGCTs) represent the most common solid tumors affecting young men. They constitute a distinct entity because of their embryonic origin and their unique biological behavior. Recent preclinical data regarding biological signaling machinery as well as genetic and epigenetic mechanisms associated with molecular patterns of tumors have contribute to explain the pathogenesis and the differentiation of TGCTs and to understand the mechanisms responsible for the development of resistance to treatment. In this review, we discuss the main genetic and epigenetic events associated with TGCTs development in order to better define their role in the pathogenesis of these tumors and in cisplatin-acquired resistance.
2018
Exploring the molecular aspects associated with testicular germ cell tumors: A review / Facchini, Gaetano; Rossetti, Sabrina; Cavaliere, Carla; D'Aniello, Carmine; DE FRANCO, Rossella; Iovane, Gelsomina; Grimaldi, Giovanni; Piscitelli, Raffaele; Muto, Paolo; Botti, Gerardo; Perdonà, Sisto; Veneziani, Bianca Maria; Berretta, Massimiliano; Montanari, Micaela. - In: ONCOTARGET. - ISSN 1949-2553. - 9:1(2018), pp. 1365-1379. [10.18632/oncotarget.22373]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/697592
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