OBJECTIVE: We evaluated the prognostic impact of quantitative assessment by maximum standardized uptake value (SUVmax), metabolic tumour volume (MTV) and tumour lesion glycolysis (TLG) on [F-18] FDG PET/CT for patients with peritoneal carcinomatosis from epithelial ovarian cancer (EOC). METHODS: Thirty-one patients with EOC underwent PET/CT for an early restaging after cytoreductive surgery, having been diagnosed with carcinomatosis (before chemotherapy). The SUVmax, MTV (cm3; 42% threshold) and TLG (g) were registered on residual peritoneal lesions. The patients were followed up 20±12months thereafter. The PET/CT results were compared to overall survival (OS). RESULTS: The Kaplan-Meier survival analysis for the SUVmax did not reveal significant differences in OS (p=0.48). The MTV survival analysis showed a significant higher OS in patients presenting with a higher tumour burden than those with less tumour burden (p=0.01; 26 vs. 14 months), whereas TLG exhibited a similar trend though not significant (p=0.06). Apart from chemo-resistance, the higher the MTV, the better will be the response to chemotherapy. CONCLUSIONS: Quantitative assessment by MTV rather than by SUVmax and TLG on PET/CT may be helpful for stratifying patients who present with peritoneal carcinomatosis from EOC, in order to implement the appropriate therapeutic regimen.

F-18 FDG PET/CT metabolic tumor volume predicts overall survival in patients with disseminated epithelial ovarian cancer / Gallicchio, Rosj; Nardelli, Anna; Venetucci, ANGELA ASSUNTA; Capacchione, Daniela; Pelagalli, Alessandra; Sirignano, Cesare; Mainenti, Pierpaolo; Pedicini, Piernicola; Guglielmi, Giuseppe; Storto, Giovanni. - In: EUROPEAN JOURNAL OF RADIOLOGY. - ISSN 0720-048X. - 93:(2017), pp. 107-113. [10.1016/j.ejrad.2017.05.036]

F-18 FDG PET/CT metabolic tumor volume predicts overall survival in patients with disseminated epithelial ovarian cancer

Gallicchio, Rosj;Nardelli, Anna;VENETUCCI, ANGELA ASSUNTA;CAPACCHIONE, DANIELA;Pelagalli, Alessandra;Storto, Giovanni
2017

Abstract

OBJECTIVE: We evaluated the prognostic impact of quantitative assessment by maximum standardized uptake value (SUVmax), metabolic tumour volume (MTV) and tumour lesion glycolysis (TLG) on [F-18] FDG PET/CT for patients with peritoneal carcinomatosis from epithelial ovarian cancer (EOC). METHODS: Thirty-one patients with EOC underwent PET/CT for an early restaging after cytoreductive surgery, having been diagnosed with carcinomatosis (before chemotherapy). The SUVmax, MTV (cm3; 42% threshold) and TLG (g) were registered on residual peritoneal lesions. The patients were followed up 20±12months thereafter. The PET/CT results were compared to overall survival (OS). RESULTS: The Kaplan-Meier survival analysis for the SUVmax did not reveal significant differences in OS (p=0.48). The MTV survival analysis showed a significant higher OS in patients presenting with a higher tumour burden than those with less tumour burden (p=0.01; 26 vs. 14 months), whereas TLG exhibited a similar trend though not significant (p=0.06). Apart from chemo-resistance, the higher the MTV, the better will be the response to chemotherapy. CONCLUSIONS: Quantitative assessment by MTV rather than by SUVmax and TLG on PET/CT may be helpful for stratifying patients who present with peritoneal carcinomatosis from EOC, in order to implement the appropriate therapeutic regimen.
2017
F-18 FDG PET/CT metabolic tumor volume predicts overall survival in patients with disseminated epithelial ovarian cancer / Gallicchio, Rosj; Nardelli, Anna; Venetucci, ANGELA ASSUNTA; Capacchione, Daniela; Pelagalli, Alessandra; Sirignano, Cesare; Mainenti, Pierpaolo; Pedicini, Piernicola; Guglielmi, Giuseppe; Storto, Giovanni. - In: EUROPEAN JOURNAL OF RADIOLOGY. - ISSN 0720-048X. - 93:(2017), pp. 107-113. [10.1016/j.ejrad.2017.05.036]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/696875
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