PDR is characterized by neovascularization and a persistent grade of inflammation. N-formyl peptide receptors (FPRs) belong to a transmembrane G protein-coupled receptor superfamily able to modulate angiogenic and inflammatory responses. However, their involvement in PDR remains to be elucidated. Here, we examined FPR expression in human umbilical vein endothelial cells (HUVECs). We further assessed the capacity of vitreous fluid obtained from PDR patients after pars plana vitrectomy to induce pro-angiogenic/pro-inflammatory responses in endothelium and the contribution of FPR inhibitors to abrogate these responses.
Involvement of N-formyl peptide receptors in modulating the pro-angiogenic/pro-inflammatory activity of human vitreous in proliferative diabetic retinopathy (PDR) / Imtiaz Nawaz, Mohd; Rezzola, Sara; Corsini, Michela; Chiodelli, Paola; Cancarini, Anna; Coltrini, Daniela; Mitola, Stefania; Ronca, Roberto; Belleri, Mirella; Lista, Liliana; Rusciano, Dario; De Rosa, Mario; Pavone, Vincenzo; Semeraro, Francesco; Presta, Marco. - In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. - ISSN 0146-0404. - 58:8(2017), pp. 5209-5209.
Involvement of N-formyl peptide receptors in modulating the pro-angiogenic/pro-inflammatory activity of human vitreous in proliferative diabetic retinopathy (PDR)
Liliana Lista;Vincenzo Pavone;
2017
Abstract
PDR is characterized by neovascularization and a persistent grade of inflammation. N-formyl peptide receptors (FPRs) belong to a transmembrane G protein-coupled receptor superfamily able to modulate angiogenic and inflammatory responses. However, their involvement in PDR remains to be elucidated. Here, we examined FPR expression in human umbilical vein endothelial cells (HUVECs). We further assessed the capacity of vitreous fluid obtained from PDR patients after pars plana vitrectomy to induce pro-angiogenic/pro-inflammatory responses in endothelium and the contribution of FPR inhibitors to abrogate these responses.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.