Cow's milk allergy (CMA) is one of the most common food allergies in children. Epigenetic mechanisms have been suggested to play a role in CMA pathogenesis. We shown that DNA methylation of Th1/Th2 cytokine genes and FoxP3 affects CMA disease course. Preliminary evidence suggest that also the miRNome could be implicated in the pathogenesis of allergy. Main study outcome was to comparatively evaluate miRNome in children with CMA and in healthy controls.
Altered miR-193a-5p expression in children with cow's milk allergy / D'Argenio, V.; Del Monaco, V.; Paparo, L.; De Palma, F. D. E.; Nocerino, R.; D'Alessio, F.; Visconte, F.; Discepolo, V.; Del Vecchio, L.; Salvatore, F.; Berni Canani, R.. - In: ALLERGY. - ISSN 0105-4538. - 73:2(2018), pp. 379-386. [10.1111/all.13299]
Altered miR-193a-5p expression in children with cow's milk allergy
V. D'Argenio;V. Del Monaco;L. Paparo;F. D. E. De Palma;R. Nocerino;F. Visconte;V. Discepolo;L. Del Vecchio;F. Salvatore;R. Berni Canani
2018
Abstract
Cow's milk allergy (CMA) is one of the most common food allergies in children. Epigenetic mechanisms have been suggested to play a role in CMA pathogenesis. We shown that DNA methylation of Th1/Th2 cytokine genes and FoxP3 affects CMA disease course. Preliminary evidence suggest that also the miRNome could be implicated in the pathogenesis of allergy. Main study outcome was to comparatively evaluate miRNome in children with CMA and in healthy controls.| File | Dimensione | Formato | |
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