Adenomyosis is a uterine disorder characterized by dysmenorrhea, dyspareunia, abnormal uterine bleeding, and infertility. Pathogenesis indicates that endometrial cells invade and proliferate within myometrium, and inflammatory mediators participate to the intense painful symptoms. The aim of the present study was to investigate the messenger RNA (mRNA) and protein expression of inflammatory (interleukin 1β [IL-1β], corticotropin-releasing hormone [CRH], urocortin [Ucn]) and neurogenic (nerve growth factors [NGFs], synaptophysin [SYN], microtubule-associated protein 2 [MAP2]) factors in adenomyotic nodules.
Expression of Inflammatory and Neurogenic Mediators in Adenomyosis / Carrarelli, Patrizia; Yen, Chih Feng; Funghi, Lucia; Arcuri, Felice; Tosti, Claudia; Bifulco, Giuseppe; Luddi, Alice; Lee, Chyi Long; Petraglia, Felice. - In: REPRODUCTIVE SCIENCES. - ISSN 1933-7191. - 24:3(2017), pp. 369-375. [10.1177/1933719116657192]
Expression of Inflammatory and Neurogenic Mediators in Adenomyosis
BIFULCO, GIUSEPPE;
2017
Abstract
Adenomyosis is a uterine disorder characterized by dysmenorrhea, dyspareunia, abnormal uterine bleeding, and infertility. Pathogenesis indicates that endometrial cells invade and proliferate within myometrium, and inflammatory mediators participate to the intense painful symptoms. The aim of the present study was to investigate the messenger RNA (mRNA) and protein expression of inflammatory (interleukin 1β [IL-1β], corticotropin-releasing hormone [CRH], urocortin [Ucn]) and neurogenic (nerve growth factors [NGFs], synaptophysin [SYN], microtubule-associated protein 2 [MAP2]) factors in adenomyotic nodules.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
