Introduction. Evidences suggest that vascular calcification (VC) lead to a poor cardiovascular (CV) prognosis in patients undergoing maintenance dialysis (CKD-5). Nonetheless, how VC might predispose to cardiovascular mortality still remains to be clarified. Herein, we report on the association between coronary artery calcification (CAC) progression and changes in cardiac repolarization as well as arterial stiffness. Methods. 132 patients new to dialysis were identified. Demographic and clinical characteristics were collected at study entry and during the 12 months follow-up. CAC, 12 leads ECG and pulse wave velocity were assessed at baseline and study completion. Univariable and multivariable analyses were applied to detect factors associated with worsening of cardiac repolarization (QTd) and arterial stiffness. Results. Univariable and multivariable analyses that revealed CAC progression was associated with a significant increase in both QTd and PWV. Every 20 unit increase in CACS corresponded to a significant 23% (95% CI: 1.12-1.27; p<0.001) and 32% (95%CI: 1.09-1.37; p<0.01) increase in the risk of experiencing 1 m/sec increase in PWV and 1 msec in QT-d, respectively.
CORONARY ARTERY CALCIFICATION PROGRESSIO N IS ASSOCIATED WITH ARTERIAL STIFFNESS AND CARDIAC REPOLARIZATION DETERIORATION IN HEMODIALYSIS PATIENTS / Torraca, S.; Di Micco, L.; Sirico, M. L.; Russo, Domenico; Bellasi, A.; Di Iorio, B.. - In: GIORNALE ITALIANO DI NEFROLOGIA. - ISSN 1724-5990. - (2011). (Intervento presentato al convegno 52° Congresso Nazionale della Società Italiana di Nefrologia. Genova, 21-24 Settembre 2011 tenutosi a Genova nel 21-24 Settembre 2011).
CORONARY ARTERY CALCIFICATION PROGRESSIO N IS ASSOCIATED WITH ARTERIAL STIFFNESS AND CARDIAC REPOLARIZATION DETERIORATION IN HEMODIALYSIS PATIENTS
RUSSO, DOMENICO;
2011
Abstract
Introduction. Evidences suggest that vascular calcification (VC) lead to a poor cardiovascular (CV) prognosis in patients undergoing maintenance dialysis (CKD-5). Nonetheless, how VC might predispose to cardiovascular mortality still remains to be clarified. Herein, we report on the association between coronary artery calcification (CAC) progression and changes in cardiac repolarization as well as arterial stiffness. Methods. 132 patients new to dialysis were identified. Demographic and clinical characteristics were collected at study entry and during the 12 months follow-up. CAC, 12 leads ECG and pulse wave velocity were assessed at baseline and study completion. Univariable and multivariable analyses were applied to detect factors associated with worsening of cardiac repolarization (QTd) and arterial stiffness. Results. Univariable and multivariable analyses that revealed CAC progression was associated with a significant increase in both QTd and PWV. Every 20 unit increase in CACS corresponded to a significant 23% (95% CI: 1.12-1.27; p<0.001) and 32% (95%CI: 1.09-1.37; p<0.01) increase in the risk of experiencing 1 m/sec increase in PWV and 1 msec in QT-d, respectively.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
