NERVOUS SYSTEM IN RENAL TRANSPLANTED PATIENTS

Chronic renal failure greatly affects central (CNS) and peripheral (PNS) nervous system function. This study evaluates effects of renal transplantation (TX) on CNS and PNS anomalies after TX. Sensory and motor nerves conduction velocity (SCV and MCV) measurement, somatosensory evoked potentials (SEPs), transcranial magnetic stimulation with the evaluation of central motor conduction time (CMCT), central silent period (cSP) and central motor threshold (cMT) were performed in ten transplanted patients (7 M and 3 F), within 2 months since TX (T0) and 1 year later (T1). Results Pts with abnormal findings at T0 Pts with abnormal findings at T1 SCV-MCV 6 4 CMCT 5 4 SEPs 2 1 Mean value of upper (7.7 ms) and lower (13.4 ms) CMCT were significantly increased at T0 and T1 when compared to control group (p<0.019 and p<0.0003 respectively). Mean value of cMT and of cSP were significantly increased (77.5% and 72%, p<0.0001) at T0 and both became normal at T1 (56% and 48% respectively). Conclusion: our data show that TX patients had an high incidence of PNS and of cortical motor system (CMCT, cSP and cMT) involvement. TX plays an important role mainly in reverting functional abnormalities in cortical motor system, at least after 1 year since TX. Session: 2002 Poster Session