The aim of this work was to investigate the efficacy of sequential treatment with first-, second- and third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors and the mechanisms of acquired resistance occurring during the sequential use of these inhibitors.
Efficacy of continuous EGFR-inhibition and role of Hedgehog in EGFR acquired resistance in human lung cancer cells with activating mutation of EGFR / Della Corte, Carminia Maria; Malapelle, Umberto; Vigliar, Elena; Pepe, Francesco; Troncone, Giancarlo; Ciaramella, Vincenza; Troiani, Teresa; Martinelli, Erika; Belli, Valentina; Ciardiello, Fortunato; Morgillo, Floriana. - In: ONCOTARGET. - ISSN 1949-2553. - 8:14(2017), p. 23020-23032. [10.18632/oncotarget.15479]
Efficacy of continuous EGFR-inhibition and role of Hedgehog in EGFR acquired resistance in human lung cancer cells with activating mutation of EGFR
MALAPELLE, UMBERTO;VIGLIAR, ELENA;PEPE, FRANCESCO;TRONCONE, GIANCARLO;TROIANI, TERESA;BELLI, VALENTINA;CIARDIELLO, FORTUNATO;
2017
Abstract
The aim of this work was to investigate the efficacy of sequential treatment with first-, second- and third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors and the mechanisms of acquired resistance occurring during the sequential use of these inhibitors.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
