Several studies have focused on the antifibrotic potential of the Th1 cytokine IFN-γ-1b through suppression of Th2 fibrogenic functions. It has been reported that IFN-γ induces the production of CXCL11 in the lung and plasma of patients with lung-fibrosis. The aim of the present study was to determine whether the levels of CXCL11 in the bronchoalveolar lavage fluid (BALF) of SSc patients might be a predictor of clinically significant fibrotic lung involvement.

CXCL11 in bronchoalveolar lavage fluid and pulmonary function decline in systemic sclerosis / Sfriso, Paolo; Cozzi, Franco; Oliviero, Francesca; Caso, Francesco; Cardarelli, Silvia; Facco, Monica; Fittà, Claudio; Del Rosso, Angela; Matucci Cerinic, Marco; Punzi, Leonardo; Agostini, Carlo. - In: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. - ISSN 0392-856X. - 30:2 Suppl 71(2012), pp. 71-75.

CXCL11 in bronchoalveolar lavage fluid and pulmonary function decline in systemic sclerosis

CASO, FRANCESCO;
2012

Abstract

Several studies have focused on the antifibrotic potential of the Th1 cytokine IFN-γ-1b through suppression of Th2 fibrogenic functions. It has been reported that IFN-γ induces the production of CXCL11 in the lung and plasma of patients with lung-fibrosis. The aim of the present study was to determine whether the levels of CXCL11 in the bronchoalveolar lavage fluid (BALF) of SSc patients might be a predictor of clinically significant fibrotic lung involvement.
2012
CXCL11 in bronchoalveolar lavage fluid and pulmonary function decline in systemic sclerosis / Sfriso, Paolo; Cozzi, Franco; Oliviero, Francesca; Caso, Francesco; Cardarelli, Silvia; Facco, Monica; Fittà, Claudio; Del Rosso, Angela; Matucci Cerinic, Marco; Punzi, Leonardo; Agostini, Carlo. - In: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. - ISSN 0392-856X. - 30:2 Suppl 71(2012), pp. 71-75.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/681866
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