Accuracy in Diagnosis of Celiac Disease Without Biopsies in Clinical Practice

Werkstetter, K. J; Korponay Szabó, I. R; Popp, A; Villanacci, V; Salemme, M; Heilig, G; Lillevang, S. T; Mearin, M. L; Ribes Koninckx, C; Thomas, A; Troncone, Riccardo; Filipiak, B; Mäki, M; Gyimesi, J; Najafi, M; Dolinšek, J; Dydensborg Sander, S; Auricchio, Renata; Papadopoulou, A; Vécsei, A; Szitanyi, P; Donat, E; Nenna, R; Alliet, Ph; Penagini, F; Garnier Lengliné, H; Castillejo, G; Kurppa, K; Shamir, R; Hauer, A. C; Smets, F; Corujeira, S; van Winckel, M; Buderus, S; Chong, S; Husby, S; Koletzko, S; Socha, Piotr; Bozena Cukrowska, Null; Szajewska, Hania; Wyhowski, Jan; Brown, Nailah; Batra, Gauri; Misak, Zrinjka; Seiwerth, Sven; Dmitrieva, Yulia; Abramov, Dmitry; Vandenplas, Yvan; Goossens, Annieta; Schaart, Maaike W; Smit, V. T. H. B. M; Kalach, Nicolas; Gosset, Pierre; Kovács, Judit B; Nagy, Anikó; Lellei, Ilona; Kőbányai, Rita; Khatami, Katayoun; Monajemzadeh, Maryam; Dimakou, Konstantina; Patereli, Amalia; Plato Hansen, Tine; Kavalar, Rajko; Bolonio, Miguel; Kogler, Hubert; Amann, Gabriele; Kosova, Roberta; Maglio, Mariantonia; Janssens, Elke; Achten, Ruth; Frűhauf, Pavel; Skálová, Helena; Kirchner, Thomas; Petrarca, Laura; Magliocca, Fabio Massimo; Martínez, Francesc; Morente, Vanesa; Thanner Lechner, Sonja; Ratschek, Manfred; Gasparetto, Marco; Hook, Liz; Canioni, Danielle; Wanty, Catherine; Mourin, Anne; Laurila, Kaija; Vornane, Martine; Nachmias Friedler, Vered; Morgenstern, Sara L; Amil Dias, Jorge; Carneiro, Fátima; Van Biervliet, Stephanie; Vande Velde, Saskia; Banoub, Hany; Sampson, Steve; Müller, Annette M; Ene, Adina; Rafeey, Mandana; Eftekhar Sadat, Iran Amir Taher

doi:10.1053/j.gastro.2017.06.002

The guidelines of the European Society of Pediatric Gastroenterology, Hepatology, and Nutrition allow for diagnosis of celiac disease without biopsies in children with symptoms and levels of immunoglobulin A against tissue-transglutaminase (TGA-IgA) 10-fold or more the upper limit of normal (ULN), confirmed by detection of endomysium antibodies (EMA) and positivity for HLA-DQ2/DQ8. We performed a large, international prospective study to validate this approach.

Accuracy in Diagnosis of Celiac Disease Without Biopsies in Clinical Practice / Werkstetter, K. J; Korponay Szabó, I. R; Popp, A; Villanacci, V; Salemme, M; Heilig, G; Lillevang, S. T; Mearin, M. L; Ribes Koninckx, C; Thomas, A; Troncone, Riccardo; Filipiak, B; Mäki, M; Gyimesi, J; Najafi, M; Dolinšek, J; Dydensborg Sander, S; Auricchio, Renata; Papadopoulou, A; Vécsei, A; Szitanyi, P; Donat, E; Nenna, R; Alliet, Ph; Penagini, F; Garnier Lengliné, H; Castillejo, G; Kurppa, K; Shamir, R; Hauer, A. C; Smets, F; Corujeira, S; van Winckel, M; Buderus, S; Chong, S; Husby, S; Koletzko, S; Socha, Piotr; Bozena Cukrowska, Null; Szajewska, Hania; Wyhowski, Jan; Brown, Nailah; Batra, Gauri; Misak, Zrinjka; Seiwerth, Sven; Dmitrieva, Yulia; Abramov, Dmitry; Vandenplas, Yvan; Goossens, Annieta; Schaart, Maaike W; Smit, V. T. H. B. M; Kalach, Nicolas; Gosset, Pierre; Kovács, Judit B; Nagy, Anikó; Lellei, Ilona; Kőbányai, Rita; Khatami, Katayoun; Monajemzadeh, Maryam; Dimakou, Konstantina; Patereli, Amalia; Plato Hansen, Tine; Kavalar, Rajko; Bolonio, Miguel; Kogler, Hubert; Amann, Gabriele; Kosova, Roberta; Maglio, Mariantonia; Janssens, Elke; Achten, Ruth; Frűhauf, Pavel; Skálová, Helena; Kirchner, Thomas; Petrarca, Laura; Magliocca, Fabio Massimo; Martínez, Francesc; Morente, Vanesa; Thanner Lechner, Sonja; Ratschek, Manfred; Gasparetto, Marco; Hook, Liz; Canioni, Danielle; Wanty, Catherine; Mourin, Anne; Laurila, Kaija; Vornane, Martine; Nachmias Friedler, Vered; Morgenstern, Sara L; Amil Dias, Jorge; Carneiro, Fátima; Van Biervliet, Stephanie; Vande Velde, Saskia; Banoub, Hany; Sampson, Steve; Müller, Annette M; Ene, Adina; Rafeey, Mandana; Eftekhar Sadat, Iran Amir Taher. - In: GASTROENTEROLOGY. - ISSN 0016-5085. - (2017). [10.1053/j.gastro.2017.06.002]