The full absolute configuration assignment of phosphoeleganin (1), a recently discovered marine-derived phosphorylated polyketide with protein tyrosine phosphatase 1B inhibitory activity, was achieved. It was based on the synthesis of model diasteroisomeric compounds of the C-8-C-12 segment portion of phosphoeleganin, chiral derivatization methods, and application of the universal NMR database concept.

Assignment of the Absolute Configuration of Phosphoeleganin via Synthesis of Model Compounds / Luciano, Paolo; Imperatore, Concetta; Senese, Maria; Aiello, Anna; Casertano, Marcello; Guo, Yue W; Menna, Marialuisa. - In: JOURNAL OF NATURAL PRODUCTS. - ISSN 0163-3864. - 80:7(2017), pp. 2118-2123. [10.1021/acs.jnatprod.7b00397]

Assignment of the Absolute Configuration of Phosphoeleganin via Synthesis of Model Compounds

LUCIANO, PAOLO
Co-primo
;
IMPERATORE, CONCETTA
Co-primo
;
SENESE, MARIA;AIELLO, ANNA;CASERTANO, MARCELLO;MENNA, MARIALUISA
Ultimo
2017

Abstract

The full absolute configuration assignment of phosphoeleganin (1), a recently discovered marine-derived phosphorylated polyketide with protein tyrosine phosphatase 1B inhibitory activity, was achieved. It was based on the synthesis of model diasteroisomeric compounds of the C-8-C-12 segment portion of phosphoeleganin, chiral derivatization methods, and application of the universal NMR database concept.
2017
Assignment of the Absolute Configuration of Phosphoeleganin via Synthesis of Model Compounds / Luciano, Paolo; Imperatore, Concetta; Senese, Maria; Aiello, Anna; Casertano, Marcello; Guo, Yue W; Menna, Marialuisa. - In: JOURNAL OF NATURAL PRODUCTS. - ISSN 0163-3864. - 80:7(2017), pp. 2118-2123. [10.1021/acs.jnatprod.7b00397]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/680960
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