The full absolute configuration assignment of phosphoeleganin (1), a recently discovered marine-derived phosphorylated polyketide with protein tyrosine phosphatase 1B inhibitory activity, was achieved. It was based on the synthesis of model diasteroisomeric compounds of the C-8-C-12 segment portion of phosphoeleganin, chiral derivatization methods, and application of the universal NMR database concept.

Assignment of the Absolute Configuration of Phosphoeleganin via Synthesis of Model Compounds

LUCIANO, PAOLO
Co-primo
;
IMPERATORE, CONCETTA
Co-primo
;
SENESE, MARIA;AIELLO, ANNA;CASERTANO, MARCELLO;MENNA, MARIALUISA
Ultimo
2017

Abstract

The full absolute configuration assignment of phosphoeleganin (1), a recently discovered marine-derived phosphorylated polyketide with protein tyrosine phosphatase 1B inhibitory activity, was achieved. It was based on the synthesis of model diasteroisomeric compounds of the C-8-C-12 segment portion of phosphoeleganin, chiral derivatization methods, and application of the universal NMR database concept.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/680960
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