The full absolute configuration assignment of phosphoeleganin (1), a recently discovered marine-derived phosphorylated polyketide with protein tyrosine phosphatase 1B inhibitory activity, was achieved. It was based on the synthesis of model diasteroisomeric compounds of the C-8-C-12 segment portion of phosphoeleganin, chiral derivatization methods, and application of the universal NMR database concept.
Assignment of the Absolute Configuration of Phosphoeleganin via Synthesis of Model Compounds
LUCIANO, PAOLOCo-primo
;IMPERATORE, CONCETTACo-primo
;SENESE, MARIA;AIELLO, ANNA;CASERTANO, MARCELLO;MENNA, MARIALUISA
Ultimo
2017
Abstract
The full absolute configuration assignment of phosphoeleganin (1), a recently discovered marine-derived phosphorylated polyketide with protein tyrosine phosphatase 1B inhibitory activity, was achieved. It was based on the synthesis of model diasteroisomeric compounds of the C-8-C-12 segment portion of phosphoeleganin, chiral derivatization methods, and application of the universal NMR database concept.File in questo prodotto:
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