Adrenal incidentalomas (AIs) and polycystic ovary syndrome (PCOS) have often been associated with compensatory hyperinsulinemia and insulin resistance (IR). The link between these diseases and IR may be changes in hormone secretions that provoke IR and in turn promote the growth of adrenal gland masses and/or ovarian cysts through compensatory hyperinsulinemia.
Insulin-Mediated Diseases: Adrenal Mass and Polycystic Ovary Syndrome / Muscogiuri, Giovanna; Colao, Annamaria; Orio, Francesco. - In: TRENDS IN ENDOCRINOLOGY AND METABOLISM. - ISSN 1043-2760. - 26:10(2015), pp. 512-4-514. [10.1016/j.tem.2015.07.010]