Leptin is an adipocyte-derived hormone/cytokine that links nutritional status with neuroendocrine and immune functions. Initially described as an anti-obesity hormone, leptin has subsequently been shown to exert pleiotropic effects, being also able to influence haematopoiesis, thermogenesis, reproduction, angiogenesis, and more importantly immune homeostasis. As a cytokine, leptin can affect both innate and adaptive immunity, by inducing a pro-inflammatory response and thus playing a key role in the regulation of the pathogenesis of several autoimmune/inflammatory diseases. In this review, we discuss the most recent advances on the role of leptin as immune-modulator in mammals and we also provide an overview on its main functions in non-mammalian vertebrates.
Leptin as immune mediator: Interaction between neuroendocrine and immune system / Procaccini, Claudio; LA ROCCA, Claudia; Carbone, Fortunata; DE ROSA, Veronica; Galgani, Mario; Matarese, Giuseppe. - In: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY. - ISSN 0145-305X. - 66:(2017), pp. 120-129. [10.1016/j.dci.2016.06.006]
Leptin as immune mediator: Interaction between neuroendocrine and immune system
PROCACCINI, CLAUDIO;LA ROCCA, CLAUDIA;CARBONE, FORTUNATA;DE ROSA, VERONICA;GALGANI, MARIO;MATARESE, GIUSEPPE
2017
Abstract
Leptin is an adipocyte-derived hormone/cytokine that links nutritional status with neuroendocrine and immune functions. Initially described as an anti-obesity hormone, leptin has subsequently been shown to exert pleiotropic effects, being also able to influence haematopoiesis, thermogenesis, reproduction, angiogenesis, and more importantly immune homeostasis. As a cytokine, leptin can affect both innate and adaptive immunity, by inducing a pro-inflammatory response and thus playing a key role in the regulation of the pathogenesis of several autoimmune/inflammatory diseases. In this review, we discuss the most recent advances on the role of leptin as immune-modulator in mammals and we also provide an overview on its main functions in non-mammalian vertebrates.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
