The therapeutic HIV-1 Tat protein vaccine is in advanced clinical development. Tuberculosis, the main AIDS co-infection, is highly endemic in areas where AIDS prevention through vaccination is needed. However, safety and immunogenicity of Tat vaccination in the course of Mycobacterium tuberculosis (Mtb) infection is still unknown and it prevents the possibility to administer the vaccine to Mtb-infected individuals. We addressed the interplay and effects of Tat vaccination on Mtb infection in immunocompetent mice.

HIV-1 Tat protein vaccination in mice infected with Mycobacterium tuberculosis is safe, immunogenic and reduces bacterial lung pathology / Cafaro, A., Piccaro, G., Altavilla, G., Gigantino, V., Matarese, G., Olivieri, E., Ferrantelli, F., Ensoli, B., Palma, C.. - In: BMC INFECTIOUS DISEASES. - ISSN 1471-2334. - 16:1(2016), p. 442. [10.1186/s12879-016-1724-7]

HIV-1 Tat protein vaccination in mice infected with Mycobacterium tuberculosis is safe, immunogenic and reduces bacterial lung pathology

MATARESE, GIUSEPPE;
2016

Abstract

The therapeutic HIV-1 Tat protein vaccine is in advanced clinical development. Tuberculosis, the main AIDS co-infection, is highly endemic in areas where AIDS prevention through vaccination is needed. However, safety and immunogenicity of Tat vaccination in the course of Mycobacterium tuberculosis (Mtb) infection is still unknown and it prevents the possibility to administer the vaccine to Mtb-infected individuals. We addressed the interplay and effects of Tat vaccination on Mtb infection in immunocompetent mice.
2016
HIV-1 Tat protein vaccination in mice infected with Mycobacterium tuberculosis is safe, immunogenic and reduces bacterial lung pathology / Cafaro, A., Piccaro, G., Altavilla, G., Gigantino, V., Matarese, G., Olivieri, E., Ferrantelli, F., Ensoli, B., Palma, C.. - In: BMC INFECTIOUS DISEASES. - ISSN 1471-2334. - 16:1(2016), p. 442. [10.1186/s12879-016-1724-7]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/670550
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