Mesenchymal stem cells (MSCs) display a therapeutic plasticity because of their ability to modulate immunity, foster tissue repair, and differentiate into mesodermal cells. IFN-γ has been described to differently affect human mesenchymal stem cell (hMSC) and mouse mesenchymal stem cell (mMSC) immunomodulation and differentiation, depending on the inflammatory milieu.

IFN-γ orchestrates mesenchymal stem cell plasticity through the signal transducer and activator of transcription 1 and 3 and mammalian target of rapamycin pathways / Vigo, Tiziana; Procaccini, Claudio; Ferrara, Giovanni; Baranzini, Sergio; Oksenberg, Jorge R; Matarese, Giuseppe; Diaspro, Alberto; Kerlero de Rosbo, Nicole; Uccelli, Antonio. - In: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. - ISSN 0091-6749. - (2016). [10.1016/j.jaci.2016.09.004]

IFN-γ orchestrates mesenchymal stem cell plasticity through the signal transducer and activator of transcription 1 and 3 and mammalian target of rapamycin pathways

PROCACCINI, CLAUDIO;MATARESE, GIUSEPPE;
2016

Abstract

Mesenchymal stem cells (MSCs) display a therapeutic plasticity because of their ability to modulate immunity, foster tissue repair, and differentiate into mesodermal cells. IFN-γ has been described to differently affect human mesenchymal stem cell (hMSC) and mouse mesenchymal stem cell (mMSC) immunomodulation and differentiation, depending on the inflammatory milieu.
2016
IFN-γ orchestrates mesenchymal stem cell plasticity through the signal transducer and activator of transcription 1 and 3 and mammalian target of rapamycin pathways / Vigo, Tiziana; Procaccini, Claudio; Ferrara, Giovanni; Baranzini, Sergio; Oksenberg, Jorge R; Matarese, Giuseppe; Diaspro, Alberto; Kerlero de Rosbo, Nicole; Uccelli, Antonio. - In: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. - ISSN 0091-6749. - (2016). [10.1016/j.jaci.2016.09.004]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/670547
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