Mechanisms influencing breast cancer (BC) development and recurrence include hyperglycemia, hyperinsulinemia, high insulin-like growth factor-1, high circulating estrogen, inflammation and impaired cellular differentiation/apoptosis. A lifestyle program that targets all the above mechanisms may be warranted. Low glycemic index (GI) foods produce lower post-prandial glucose and insulin responses and have been associated with lower BC risk. Moderate physical activity post-diagnosis reduces BC recurrence and mortality, partly explained by reduced insulin and estrogen levels. Vitamin D increases cell differentiation/apoptosis and high serum vitamin D levels improve BC survival. Yet no trial has evaluated the combined effect of a low GI diet, moderate physical activity and vitamin D supplementation on BC recurrence in the context of a Mediterranean lifestyle setting.

Low glycemic index diet, exercise and vitamin D to reduce breast cancer recurrence (DEDiCa): design of a clinical trial / Augustin, Livia S. A; Libra, Massimo; Crispo, Anna; Grimaldi, Maria; DE LAURENTIIS, Michelino; Rinaldo, Massimo; D'Aiuto, Massimiliano; Catalano, Francesca; Banna, Giuseppe; Ferrau', Francesco; Rossello, Rosalba; Serraino, Diego; Bidoli, Ettore; Massarut, Samuele; Thomas, Guglielmo; Gatti, Davide; Cavalcanti, Ernesta; Pinto, Monica; Riccardi, Gabriele; Vidgen, Edward; Kendall, Cyril W. C; Jenkins, David J. A; Ciliberto, Gennaro; Montella, Maurizio. - In: BMC CANCER. - ISSN 1471-2407. - 17:1(2017), p. 69. [10.1186/s12885-017-3064-4]

Low glycemic index diet, exercise and vitamin D to reduce breast cancer recurrence (DEDiCa): design of a clinical trial

CRISPO, ANNA;DE LAURENTIIS, MICHELINO;CAVALCANTI, Ernesta;RICCARDI, GABRIELE;CILIBERTO, GENNARO;
2017

Abstract

Mechanisms influencing breast cancer (BC) development and recurrence include hyperglycemia, hyperinsulinemia, high insulin-like growth factor-1, high circulating estrogen, inflammation and impaired cellular differentiation/apoptosis. A lifestyle program that targets all the above mechanisms may be warranted. Low glycemic index (GI) foods produce lower post-prandial glucose and insulin responses and have been associated with lower BC risk. Moderate physical activity post-diagnosis reduces BC recurrence and mortality, partly explained by reduced insulin and estrogen levels. Vitamin D increases cell differentiation/apoptosis and high serum vitamin D levels improve BC survival. Yet no trial has evaluated the combined effect of a low GI diet, moderate physical activity and vitamin D supplementation on BC recurrence in the context of a Mediterranean lifestyle setting.
2017
Low glycemic index diet, exercise and vitamin D to reduce breast cancer recurrence (DEDiCa): design of a clinical trial / Augustin, Livia S. A; Libra, Massimo; Crispo, Anna; Grimaldi, Maria; DE LAURENTIIS, Michelino; Rinaldo, Massimo; D'Aiuto, Massimiliano; Catalano, Francesca; Banna, Giuseppe; Ferrau', Francesco; Rossello, Rosalba; Serraino, Diego; Bidoli, Ettore; Massarut, Samuele; Thomas, Guglielmo; Gatti, Davide; Cavalcanti, Ernesta; Pinto, Monica; Riccardi, Gabriele; Vidgen, Edward; Kendall, Cyril W. C; Jenkins, David J. A; Ciliberto, Gennaro; Montella, Maurizio. - In: BMC CANCER. - ISSN 1471-2407. - 17:1(2017), p. 69. [10.1186/s12885-017-3064-4]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/667893
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