Cross-sectional studies suggest the association between diabetic nephropathy and the PPARγ2 Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 (PPARγ2). Prospective data are limited to microalbuminuria and no information on renal function is available to date. The present study evaluates the association between the Pro12Ala polymorphism of PPARγ2 and the progression of albuminuria and decay in glomerular filtration rate (GFR) in type 2 diabetes.
The PPARγ2 Pro12Ala variant is protective against progression of nephropathy in people with type 2 diabetes / Lapice, Emanuela; Monticelli, Antonella; Cocozza, Sergio; Pinelli, Michele; Cocozza, Sara; Bruzzese, Dario; Riccardi, Gabriele; Vaccaro, Olga. - In: JOURNAL OF TRANSLATIONAL MEDICINE. - ISSN 1479-5876. - 13:1(2015), p. 85. [10.1186/s12967-015-0448-6]
The PPARγ2 Pro12Ala variant is protective against progression of nephropathy in people with type 2 diabetes
LAPICE, EMANUELA;COCOZZA, SERGIO;PINELLI, MICHELE;COCOZZA, SARA;BRUZZESE, DARIO;RICCARDI, GABRIELE;VACCARO, OLGA
2015
Abstract
Cross-sectional studies suggest the association between diabetic nephropathy and the PPARγ2 Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 (PPARγ2). Prospective data are limited to microalbuminuria and no information on renal function is available to date. The present study evaluates the association between the Pro12Ala polymorphism of PPARγ2 and the progression of albuminuria and decay in glomerular filtration rate (GFR) in type 2 diabetes.| File | Dimensione | Formato | |
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