Low vitamin D status and obesity have concomitantly reached epidemic levels worldwide. Up to now the direction of the association between low vitamin D status and obesity, the exact mechanisms responsible for this association and the clinical usefulness to increase vitamin D status for reducing adiposity still warrant further evaluation. The aim of the present review was to examine the current evidence linking low vitamin D status and obesity in relation to the role of the nutritionist. On the one side, considering obesity as a causal factor, low sun exposure in obese individuals due to their sedentary lifestyle and less outdoor activity, vitamin D sequestration in adipose tissue, and volumetric dilution of ingested or cutaneously synthesized vitamin D3 in the large fat mass of obese patients, might represent some of the factors playing a major role in the pathogenesis of the low vitamin D status. On the other side, the expression of both vitamin D3 receptors and enzymes responsible for vitamin D3 metabolism in adipocytes depicted a role for the low vitamin D status per se in the development of obesity by modulating adipocyte differentiation and lipid metabolism. Nutritionists need to accurately address the aspects influencing the low vitamin D status in obesity and the vitamin D supplementation in obese individuals.

Low vitamin D status and obesity: Role of nutritionist / Savastano, Silvia; Barrea, Luigi; Savanelli, MARIA CRISTINA; Nappi, Francesca; DI SOMMA, Carolina; Orio, Francesco; Colao, Annamaria. - In: REVIEWS IN ENDOCRINE & METABOLIC DISORDERS. - ISSN 1389-9155. - (2017). [10.1007/s11154-017-9410-7]

Low vitamin D status and obesity: Role of nutritionist

SAVASTANO, SILVIA;BARREA, LUIGI;SAVANELLI, MARIA CRISTINA;NAPPI, FRANCESCA;DI SOMMA, CAROLINA;ORIO, FRANCESCO;COLAO, ANNAMARIA
2017

Abstract

Low vitamin D status and obesity have concomitantly reached epidemic levels worldwide. Up to now the direction of the association between low vitamin D status and obesity, the exact mechanisms responsible for this association and the clinical usefulness to increase vitamin D status for reducing adiposity still warrant further evaluation. The aim of the present review was to examine the current evidence linking low vitamin D status and obesity in relation to the role of the nutritionist. On the one side, considering obesity as a causal factor, low sun exposure in obese individuals due to their sedentary lifestyle and less outdoor activity, vitamin D sequestration in adipose tissue, and volumetric dilution of ingested or cutaneously synthesized vitamin D3 in the large fat mass of obese patients, might represent some of the factors playing a major role in the pathogenesis of the low vitamin D status. On the other side, the expression of both vitamin D3 receptors and enzymes responsible for vitamin D3 metabolism in adipocytes depicted a role for the low vitamin D status per se in the development of obesity by modulating adipocyte differentiation and lipid metabolism. Nutritionists need to accurately address the aspects influencing the low vitamin D status in obesity and the vitamin D supplementation in obese individuals.
2017
Low vitamin D status and obesity: Role of nutritionist / Savastano, Silvia; Barrea, Luigi; Savanelli, MARIA CRISTINA; Nappi, Francesca; DI SOMMA, Carolina; Orio, Francesco; Colao, Annamaria. - In: REVIEWS IN ENDOCRINE & METABOLIC DISORDERS. - ISSN 1389-9155. - (2017). [10.1007/s11154-017-9410-7]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/667201
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