In their interesting research letter, Chen et al. (2016 Apr 8. doi: 10.1111/bjd.14662)(1) described the protective effects of oral nicotinamide (NCT) for chemoprevention of non-melanoma skin cancers (NMSCs) in renal transplant recipients. We totally agree that NCT can represent a new opportunity for NMSC chemoprevention basing on its capability to preserve cellular energy reserve for ATP-dependent DNA repair as well as UV-induced immunosuppression.(2) Moreover, we hypothesize that one of the mechanisms through which NCT may act is by modulating the expression of cyclooxygenase (COX)-2, the rate-limiting enzyme in prostaglandin (PG) generation. This article is protected by copyright. All rights reserved.
Nicotinamide reduces COX-2 expression in HaCaT keratinocytes after ultraviolet B irradiation / Monfrecola, Giuseppe; DI CAPRIO, Roberta; Balato, Nicola; Assunta Bevilacqua, M; Iovine, B; Lembo, Serena; Balato, Anna. - In: BRITISH JOURNAL OF DERMATOLOGY. - ISSN 0007-0963. - 24:(2017). [10.1111/bjd.15338]
Nicotinamide reduces COX-2 expression in HaCaT keratinocytes after ultraviolet B irradiation
MONFRECOLA, GIUSEPPE;DI CAPRIO, ROBERTA;BALATO, NICOLA;LEMBO, SERENA;BALATO, ANNA
2017
Abstract
In their interesting research letter, Chen et al. (2016 Apr 8. doi: 10.1111/bjd.14662)(1) described the protective effects of oral nicotinamide (NCT) for chemoprevention of non-melanoma skin cancers (NMSCs) in renal transplant recipients. We totally agree that NCT can represent a new opportunity for NMSC chemoprevention basing on its capability to preserve cellular energy reserve for ATP-dependent DNA repair as well as UV-induced immunosuppression.(2) Moreover, we hypothesize that one of the mechanisms through which NCT may act is by modulating the expression of cyclooxygenase (COX)-2, the rate-limiting enzyme in prostaglandin (PG) generation. This article is protected by copyright. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
