Onopordumillyricum L. is a medicinal plant used in theMediterranean area as antipyretic for the treatment of respiratory and urinary inflammations and to treat skin ulcers. Repeated chromatographic purification of O. illyricum aerial parts led to the isolation of six known sesquiterpenes, which were evaluated for the inhibition of the pro-inflammatory transcription factors NF-κB and STAT3 and for the activation of the transcription factor Nrf2, which regulates the cellular antioxidant response. Structure–activity relationships were interpreted by the NMR-based cysteamine assay. The sesquiterpene lactone vernomelitensin significantly inhibited NF-κB and STAT3, showing also a significant Nrf2 activation. Accordingly, the cysteamine assay selected vernomelitensin as the most reactive of the isolated sesquiterpenes, identifying the α,β-unsaturated aldehyde moiety as responsible for the higher (re)activity.

Anti-inflammatory sesquiterpene lactones from onpordum illyricum L. (Asteraceae), an Italian medicinal plant / Formisano, Carmen; Sanna, C.; Ballero, M.; Chianese, G.; Sirignano, Carmina; Rigano, Daniela; Millan, E.; Munoz, E.; TAGLIALATELA SCAFATI, Orazio. - In: FITOTERAPIA. - ISSN 1971-551X. - 116:(2017), pp. 61-65. [10.1016/j.fitote.2016.11.006]

Anti-inflammatory sesquiterpene lactones from onpordum illyricum L. (Asteraceae), an Italian medicinal plant

FORMISANO, CARMEN
Primo
;
Chianese, G.;SIRIGNANO, CARMINA;RIGANO, DANIELA
;
TAGLIALATELA SCAFATI, ORAZIO
Ultimo
2017

Abstract

Onopordumillyricum L. is a medicinal plant used in theMediterranean area as antipyretic for the treatment of respiratory and urinary inflammations and to treat skin ulcers. Repeated chromatographic purification of O. illyricum aerial parts led to the isolation of six known sesquiterpenes, which were evaluated for the inhibition of the pro-inflammatory transcription factors NF-κB and STAT3 and for the activation of the transcription factor Nrf2, which regulates the cellular antioxidant response. Structure–activity relationships were interpreted by the NMR-based cysteamine assay. The sesquiterpene lactone vernomelitensin significantly inhibited NF-κB and STAT3, showing also a significant Nrf2 activation. Accordingly, the cysteamine assay selected vernomelitensin as the most reactive of the isolated sesquiterpenes, identifying the α,β-unsaturated aldehyde moiety as responsible for the higher (re)activity.
2017
Anti-inflammatory sesquiterpene lactones from onpordum illyricum L. (Asteraceae), an Italian medicinal plant / Formisano, Carmen; Sanna, C.; Ballero, M.; Chianese, G.; Sirignano, Carmina; Rigano, Daniela; Millan, E.; Munoz, E.; TAGLIALATELA SCAFATI, Orazio. - In: FITOTERAPIA. - ISSN 1971-551X. - 116:(2017), pp. 61-65. [10.1016/j.fitote.2016.11.006]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/660730
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