Objectives To evaluate changes in T1 and T2* relaxometry of dentate nuclei (DN) in respect to the number of previous administrations of Gadolinium-Based Contrast Agents (GBCA). Methods In 74 Relapsing-Remitting Multiple Sclerosis (RR-MS) patients with variable disease duration (9.8±6.8 years) and severity (Expanded Disability Status Scale scores:3.1±0.9), the DN R1 (1/T1) and R2* (1/T2*) relaxation rates were measured using two unenhanced 3D Dual-Echo spoiled Gradient-Echo sequences with different flip angles. Correlations of the number of previous GBCA administrations with DN R1 and R2* relaxation rates were tested, including gender and age effect, in a multivariate regression analysis. Results The DN R1 (normalized by brainstem) significantly correlated with the number of GBCA administrations (p<0.001), maintaining the same significance even when including MS-related factors. Instead, the DN R2* values correlated only with age (p=0.003), and not with GBCA administrations (p=0.67). In a subgroup of 35 patients for whom the administered GBCA subtype was known, the effect of GBCA on DN R1 appeared mainly related to linear GBCA. Conclusions In RR-MS patients, the number of previous GBCA administrations correlates with R1 relaxation rates of DN, while R2* values remain unaffected, suggesting that T1-shortening in these patients is related to the amount of Gadolinium given

In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents

TEDESCHI, ENRICO;CANNA, ANTONIETTA;COCOZZA, SIRIO;RUSSO, CARMELA;BORRELLI, PASQUALE;LANZILLO, ROBERTA;BRESCIA MORRA, VINCENZO;SALVATORE, MARCO;BRUNETTI, ARTURO;
2016

Abstract

Objectives To evaluate changes in T1 and T2* relaxometry of dentate nuclei (DN) in respect to the number of previous administrations of Gadolinium-Based Contrast Agents (GBCA). Methods In 74 Relapsing-Remitting Multiple Sclerosis (RR-MS) patients with variable disease duration (9.8±6.8 years) and severity (Expanded Disability Status Scale scores:3.1±0.9), the DN R1 (1/T1) and R2* (1/T2*) relaxation rates were measured using two unenhanced 3D Dual-Echo spoiled Gradient-Echo sequences with different flip angles. Correlations of the number of previous GBCA administrations with DN R1 and R2* relaxation rates were tested, including gender and age effect, in a multivariate regression analysis. Results The DN R1 (normalized by brainstem) significantly correlated with the number of GBCA administrations (p<0.001), maintaining the same significance even when including MS-related factors. Instead, the DN R2* values correlated only with age (p=0.003), and not with GBCA administrations (p=0.67). In a subgroup of 35 patients for whom the administered GBCA subtype was known, the effect of GBCA on DN R1 appeared mainly related to linear GBCA. Conclusions In RR-MS patients, the number of previous GBCA administrations correlates with R1 relaxation rates of DN, while R2* values remain unaffected, suggesting that T1-shortening in these patients is related to the amount of Gadolinium given
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/658029
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