Three new (1-3) cyclomyrsinane diterpenes and three new (7-9) premyrsinane diterpenes were isolated from the aerial parts of Euphorbia sogdiana Popov. Their chem. structures and relative configurations were elucidated by spectroscopic anal., including HRESIMS and 1D and 2D NMR techniques. The compds. are hexa- and penta-esters of two diterpene polyol skeletons, esterified with aliph. (acetic, propanoic, isobutanoic, tiglic and methyltiglic) and arom. (benzoic and nicotinic) acids. Three known cyclomyrsinane diterpenes (4-6), previously reported from Euphorbia tehranica (4 and 6) and Euphorbia aellenii (5), were also isolated. These structures, based on cyclomyrsinane and premyrsinane skeleta, are very rare and could be considered as taxonomic marker of the Euphorbia genus. The isolated compds. together with myrsinane (10) and tigliane (11), first reported from E. aellenii and isolated previously from this plant, were subjected to preliminary tests to evaluate cytotoxic activity against EJ-138 bladder carcinoma and Jurkat T-leukemia cells. [on SciFinder(R)]
Cyclomyrsinane and premyrsinane diterpenes from Euphorbia sogdiana Popov / Zolfaghari, Behzad; Yazdiniapour, Zeinab; Ghanadian, Mustafa; Lanzotti, Virginia. - In: TETRAHEDRON. - ISSN 0040-4020. - 72:35(2016), pp. 5394-5401. [10.1016/j.tet.2016.07.027]
Cyclomyrsinane and premyrsinane diterpenes from Euphorbia sogdiana Popov
LANZOTTI, VIRGINIA
2016
Abstract
Three new (1-3) cyclomyrsinane diterpenes and three new (7-9) premyrsinane diterpenes were isolated from the aerial parts of Euphorbia sogdiana Popov. Their chem. structures and relative configurations were elucidated by spectroscopic anal., including HRESIMS and 1D and 2D NMR techniques. The compds. are hexa- and penta-esters of two diterpene polyol skeletons, esterified with aliph. (acetic, propanoic, isobutanoic, tiglic and methyltiglic) and arom. (benzoic and nicotinic) acids. Three known cyclomyrsinane diterpenes (4-6), previously reported from Euphorbia tehranica (4 and 6) and Euphorbia aellenii (5), were also isolated. These structures, based on cyclomyrsinane and premyrsinane skeleta, are very rare and could be considered as taxonomic marker of the Euphorbia genus. The isolated compds. together with myrsinane (10) and tigliane (11), first reported from E. aellenii and isolated previously from this plant, were subjected to preliminary tests to evaluate cytotoxic activity against EJ-138 bladder carcinoma and Jurkat T-leukemia cells. [on SciFinder(R)]I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
