From the aerial parts of Euphorbia sogdiana Popov, obtusifoliol (1) and two related steroids (2-3) have been isolated and characterized along with a known cycloartane deriv. (4). The chem. structure of the obtusifoliol-related compds., obtained by 1D and 2D NMR, and MS measurements, have been detd. as: 3β,7α-dihydroxy-4α,14α-dimethyl-5α-ergosta-8,24(28)-diene-11-one (2) and 3β-hydroxy-4α,14α-dimethyl-5α-ergosta-8,24(28)-diene-1-one (3). Compd. 2 has been previously isolated from Euphorbia chamaesyce while compd. 3 was never reported before. The isolated compds. 1-4 were subjected to cytotoxic tests on the breast cancer cells, MCF-7 and MDA-MB231. Further pharmacol. tests on the more active compds. 2 and 3 indicated their action to be related to cell growth inhibitory activity and apoptotic effects on the tested cells. [on SciFinder(R)]
Obtusifoliol related steroids from Euphorbia sogdiana with cell growth inhibitory activity and apoptotic effects on breast cancer cells (MCF-7 and MDA-MB231) / Aghaei, Mahmoud; Yazdiniapour, Zeinab; Ghanadian, Mustafa; Zolfaghari, Behzad; Lanzotti, Virginia; Mirsafaee, V. a. h. i. d.. - In: STEROIDS. - ISSN 0039-128X. - 115:(2016), pp. 90-97. [10.1016/j.steroids.2016.07.008]
Obtusifoliol related steroids from Euphorbia sogdiana with cell growth inhibitory activity and apoptotic effects on breast cancer cells (MCF-7 and MDA-MB231)
LANZOTTI, VIRGINIA;
2016
Abstract
From the aerial parts of Euphorbia sogdiana Popov, obtusifoliol (1) and two related steroids (2-3) have been isolated and characterized along with a known cycloartane deriv. (4). The chem. structure of the obtusifoliol-related compds., obtained by 1D and 2D NMR, and MS measurements, have been detd. as: 3β,7α-dihydroxy-4α,14α-dimethyl-5α-ergosta-8,24(28)-diene-11-one (2) and 3β-hydroxy-4α,14α-dimethyl-5α-ergosta-8,24(28)-diene-1-one (3). Compd. 2 has been previously isolated from Euphorbia chamaesyce while compd. 3 was never reported before. The isolated compds. 1-4 were subjected to cytotoxic tests on the breast cancer cells, MCF-7 and MDA-MB231. Further pharmacol. tests on the more active compds. 2 and 3 indicated their action to be related to cell growth inhibitory activity and apoptotic effects on the tested cells. [on SciFinder(R)]I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
