Phytochem. anal. of Euphorbia sogdiana Popov, Euphorbiaceae, afforded the isolation of three new diterpenes based on the rare 6(17)-epoxylathyrane skeleton (1-3), along with a lathyrane (4), a myrsinane (5) and a tigliane (6) diterpenoids, previously isolated from Euphorbia aellenii. Their chem. structures were established through a combination of NMR spectroscopy and mass spectrometric methods. The epoxylathyranes 1-4 were tested to evaluate their cytotoxic activity against Jurkat T-leukemia and EJ-138 bladder cancer cells and their chem. analogy allowed to propose some structure activity relationships. [on SciFinder(R)]
6(17)-Epoxylathyrane diterpenes from Euphorbia sogdiana Popov with cytotoxic activity / Yazdiniapour, Zeinab; Ghanadian, Mustafa; Zolfaghari, Behzad; Lanzotti, Virginia. - In: FITOTERAPIA. - ISSN 1971-551X. - 108:(2016), pp. 87-92. [10.1016/j.fitote.2015.11.008]
6(17)-Epoxylathyrane diterpenes from Euphorbia sogdiana Popov with cytotoxic activity
LANZOTTI, VIRGINIA
2016
Abstract
Phytochem. anal. of Euphorbia sogdiana Popov, Euphorbiaceae, afforded the isolation of three new diterpenes based on the rare 6(17)-epoxylathyrane skeleton (1-3), along with a lathyrane (4), a myrsinane (5) and a tigliane (6) diterpenoids, previously isolated from Euphorbia aellenii. Their chem. structures were established through a combination of NMR spectroscopy and mass spectrometric methods. The epoxylathyranes 1-4 were tested to evaluate their cytotoxic activity against Jurkat T-leukemia and EJ-138 bladder cancer cells and their chem. analogy allowed to propose some structure activity relationships. [on SciFinder(R)]I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
