Two sapogenins, named 3-keto umbilicagenin A and B (1 and 2), possessing a novel chem. structure with a 3-keto group on the spirostane skeleton, have been isolated from Allium umbilicatum Boiss. Their chem. structure has been established through a combination of extensive spectroscopic anal., mainly NMR and mass spectrometry, and chem. methods as (25R)-3-keto-spirostan-2α,5α,6β-triol (1) and (25R)-3-keto-spirostan-2α,5α-diol (2). The isolated compds. were tested for cytotoxic activity on J-774, murine monocyte/macrophage, and WEHI-164, murine fibrosarcoma cell lines. [on SciFinder(R)]
3-Keto umbilicagenin A and B, new sapogenins from Allium umbilicatum Boiss / Sadeghi, Masoud; Zolfaghari, Behzad; Troiano, Raffaele; Lanzotti, Virginia. - In: FITOTERAPIA. - ISSN 1971-551X. - 102:(2015), pp. 198-202. [10.1016/j.fitote.2014.12.016]
3-Keto umbilicagenin A and B, new sapogenins from Allium umbilicatum Boiss
TROIANO, RAFFAELE;LANZOTTI, VIRGINIA
2015
Abstract
Two sapogenins, named 3-keto umbilicagenin A and B (1 and 2), possessing a novel chem. structure with a 3-keto group on the spirostane skeleton, have been isolated from Allium umbilicatum Boiss. Their chem. structure has been established through a combination of extensive spectroscopic anal., mainly NMR and mass spectrometry, and chem. methods as (25R)-3-keto-spirostan-2α,5α,6β-triol (1) and (25R)-3-keto-spirostan-2α,5α-diol (2). The isolated compds. were tested for cytotoxic activity on J-774, murine monocyte/macrophage, and WEHI-164, murine fibrosarcoma cell lines. [on SciFinder(R)]I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
