A new phosphorylated polyketide, phosphoeleganin (1), has been isolated from the Mediterranean ascidian Sidnyum elegans. Its structure and configuration have been determined by extensive use of 2D NMR and microscale chemical degradation and/or derivatization. Phosphoeleganin (1) inhibited the protein tyrosine phosphatase 1B (PTP1B) activity.
Structure and Configuration of Phosphoeleganin, a Protein Tyrosine Phosphatase 1B Inhibitor from the Mediterranean Ascidian Sidnyum elegans / Imperatore, Concetta; Luciano, Paolo; Aiello, Anna; Vitalone, Rocco; Irace, Carlo; Santamaria, Rita; Li, J.; Guo, Y. W.; Menna, Marialuisa. - In: JOURNAL OF NATURAL PRODUCTS. - ISSN 0163-3864. - 79:4(2016), pp. 1144-1148. [10.1021/acs.jnatprod.6b00063]
Structure and Configuration of Phosphoeleganin, a Protein Tyrosine Phosphatase 1B Inhibitor from the Mediterranean Ascidian Sidnyum elegans
IMPERATORE, CONCETTACo-primo
;LUCIANO, PAOLOCo-primo
;AIELLO, ANNA;VITALONE, ROCCO;IRACE, CARLO;SANTAMARIA, RITA;MENNA, MARIALUISA
Ultimo
2016
Abstract
A new phosphorylated polyketide, phosphoeleganin (1), has been isolated from the Mediterranean ascidian Sidnyum elegans. Its structure and configuration have been determined by extensive use of 2D NMR and microscale chemical degradation and/or derivatization. Phosphoeleganin (1) inhibited the protein tyrosine phosphatase 1B (PTP1B) activity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
