The recent introduction of iridium (Ir) into the catalytic converter has resulted in an increase of Ir levels into the environment, especially ambient air and soil. These observations suggested the need to evaluate potential toxicity due to Ir exposure. Since Ir compounds have been previously shown to cause immune sensitization in humans, the effects of Ir via drinking water for 90 days was assessed in adult female Wistar rats with respect to selected immune parameters. The Ir exposure induced dose-dependent decrease (p <.01) in T helper 1 (Th1) cytokines and increase (p <.001) in a T helper 2 (Th2) cytokine. The findings show that the Ir exposure affects an immune imbalance with a skewing toward a Th2 bias, a risk factor for asthma.

Iridium alters immune balance between t helper 1 and t helper 2 responses / Iavicoli, Ivo; Fontana, Luca; Marinaccio, Alessandro; Bergamaschi, Antonio; Calabrese, Edward J.. - In: HUMAN & EXPERIMENTAL TOXICOLOGY. - ISSN 0960-3271. - 29:3(2010), pp. 213-219. [10.1177/0960327109360215]

Iridium alters immune balance between t helper 1 and t helper 2 responses

IAVICOLI, Ivo;Fontana, Luca;
2010

Abstract

The recent introduction of iridium (Ir) into the catalytic converter has resulted in an increase of Ir levels into the environment, especially ambient air and soil. These observations suggested the need to evaluate potential toxicity due to Ir exposure. Since Ir compounds have been previously shown to cause immune sensitization in humans, the effects of Ir via drinking water for 90 days was assessed in adult female Wistar rats with respect to selected immune parameters. The Ir exposure induced dose-dependent decrease (p <.01) in T helper 1 (Th1) cytokines and increase (p <.001) in a T helper 2 (Th2) cytokine. The findings show that the Ir exposure affects an immune imbalance with a skewing toward a Th2 bias, a risk factor for asthma.
2010
Iridium alters immune balance between t helper 1 and t helper 2 responses / Iavicoli, Ivo; Fontana, Luca; Marinaccio, Alessandro; Bergamaschi, Antonio; Calabrese, Edward J.. - In: HUMAN & EXPERIMENTAL TOXICOLOGY. - ISSN 0960-3271. - 29:3(2010), pp. 213-219. [10.1177/0960327109360215]
File in questo prodotto:
File Dimensione Formato  
Hum_Exp_Toxicol-2010-Iavicoli-213-9.pdf

solo utenti autorizzati

Tipologia: Documento in Post-print
Licenza: Accesso privato/ristretto
Dimensione 304.1 kB
Formato Adobe PDF
304.1 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/653455
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 18
  • ???jsp.display-item.citation.isi??? 12
social impact