Potentially modifiable risk factors including obesity, diabetes, hypertension, and smoking are associated with Alzheimer disease (AD) and represent promising targets for intervention. However, the causality of these associations is unclear. We sought to assess the causal nature of these associations using Mendelian randomization (MR).

Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study / Østergaard, Søren D; Mukherjee, Shubhabrata; Sharp, Stephen J; Proitsi, Petroula; Lotta, Luca A; Day, Felix; Perry, John R. B; Boehme, Kevin L; Walter, Stefan; Kauwe, John S; Gibbons, Laura E; Larson, Eric B; Powell, John F; Langenberg, Claudia; Crane, Paul K; Wareham, Nicholas J; Scott, Robert A.; Panico, Salvatore. - In: PLOS MEDICINE. - ISSN 1549-1676. - 12:6(2015), p. e1001841; discussion e1001841. [10.1371/journal.pmed.1001841]

Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study

PANICO, SALVATORE
2015

Abstract

Potentially modifiable risk factors including obesity, diabetes, hypertension, and smoking are associated with Alzheimer disease (AD) and represent promising targets for intervention. However, the causality of these associations is unclear. We sought to assess the causal nature of these associations using Mendelian randomization (MR).
2015
Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study / Østergaard, Søren D; Mukherjee, Shubhabrata; Sharp, Stephen J; Proitsi, Petroula; Lotta, Luca A; Day, Felix; Perry, John R. B; Boehme, Kevin L; Walter, Stefan; Kauwe, John S; Gibbons, Laura E; Larson, Eric B; Powell, John F; Langenberg, Claudia; Crane, Paul K; Wareham, Nicholas J; Scott, Robert A.; Panico, Salvatore. - In: PLOS MEDICINE. - ISSN 1549-1676. - 12:6(2015), p. e1001841; discussion e1001841. [10.1371/journal.pmed.1001841]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/650598
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