Antibodies to citrullinated proteins (ACPA) occur years before RA diagnosis. Porphyromonas gingivalis expresses its own peptidylarginine deiminase (PPAD), and is a proposed aetiological factor for the ACPA response. Smoking is a risk factor for both ACPA-positive RA and periodontitis. We aimed to study the relation of these factors to the risk of RA in a prospective cohort.

Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case-control study / Fisher, B.A., Cartwright, A.J., Quirke, A.M., de Pablo, P., Romaguera, D., Panico, S., Mattiello, A., Gavrila, D., Navarro, C., Sacerdote, C., Vineis, P., Tumino, R., Lappin, D.F., Apatzidou, D., Apazidou, D., Culshaw, S., Potempa, J., Michaud, D.S., Riboli, E., Venables, P.J.. - In: BMC MUSCULOSKELETAL DISORDERS. - ISSN 1471-2474. - 16:(2015), p. 331. [10.1186/s12891-015-0792-y]

Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case-control study

PANICO, SALVATORE;
2015

Abstract

Antibodies to citrullinated proteins (ACPA) occur years before RA diagnosis. Porphyromonas gingivalis expresses its own peptidylarginine deiminase (PPAD), and is a proposed aetiological factor for the ACPA response. Smoking is a risk factor for both ACPA-positive RA and periodontitis. We aimed to study the relation of these factors to the risk of RA in a prospective cohort.
2015
Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case-control study / Fisher, B.A., Cartwright, A.J., Quirke, A.M., de Pablo, P., Romaguera, D., Panico, S., Mattiello, A., Gavrila, D., Navarro, C., Sacerdote, C., Vineis, P., Tumino, R., Lappin, D.F., Apatzidou, D., Apazidou, D., Culshaw, S., Potempa, J., Michaud, D.S., Riboli, E., Venables, P.J.. - In: BMC MUSCULOSKELETAL DISORDERS. - ISSN 1471-2474. - 16:(2015), p. 331. [10.1186/s12891-015-0792-y]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/650525
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