Antibodies to citrullinated proteins (ACPA) occur years before RA diagnosis. Porphyromonas gingivalis expresses its own peptidylarginine deiminase (PPAD), and is a proposed aetiological factor for the ACPA response. Smoking is a risk factor for both ACPA-positive RA and periodontitis. We aimed to study the relation of these factors to the risk of RA in a prospective cohort.

Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case-control study / Fisher, Benjamin A; Cartwright, Alison J; Quirke, Anne Marie; de Pablo, Paola; Romaguera, Dora; Panico, Salvatore; Mattiello, Amalia; Gavrila, Diana; Navarro, Carmen; Sacerdote, Carlotta; Vineis, Paolo; Tumino, Rosario; Lappin, David F; Apatzidou, Danae; Apazidou, Danae; Culshaw, Shauna; Potempa, Jan; Michaud, Dominique S; Riboli, Elio; Venables, Patrick J.. - In: BMC MUSCULOSKELETAL DISORDERS. - ISSN 1471-2474. - 16:(2015), p. 331. [10.1186/s12891-015-0792-y]

Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case-control study

PANICO, SALVATORE;
2015

Abstract

Antibodies to citrullinated proteins (ACPA) occur years before RA diagnosis. Porphyromonas gingivalis expresses its own peptidylarginine deiminase (PPAD), and is a proposed aetiological factor for the ACPA response. Smoking is a risk factor for both ACPA-positive RA and periodontitis. We aimed to study the relation of these factors to the risk of RA in a prospective cohort.
2015
Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case-control study / Fisher, Benjamin A; Cartwright, Alison J; Quirke, Anne Marie; de Pablo, Paola; Romaguera, Dora; Panico, Salvatore; Mattiello, Amalia; Gavrila, Diana; Navarro, Carmen; Sacerdote, Carlotta; Vineis, Paolo; Tumino, Rosario; Lappin, David F; Apatzidou, Danae; Apazidou, Danae; Culshaw, Shauna; Potempa, Jan; Michaud, Dominique S; Riboli, Elio; Venables, Patrick J.. - In: BMC MUSCULOSKELETAL DISORDERS. - ISSN 1471-2474. - 16:(2015), p. 331. [10.1186/s12891-015-0792-y]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/650525
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