Obesity is associated with an increased risk of a number of serious medical conditions, including cancer. As far as prostate cancer is concerned, obesity is associated with an increased risk of high-grade tumors, which is possibly related to lower androgen levels. Diet may also affect prostate cancer risk since countries with a higher dietary fat intake also present higher prostate cancer mortality rates. Interestingly, prostate cancer is associated with a number of metabolic alterations that may provide valuable diagnostic and therapeutic targets. This review explores the available clinical as well as biological evidence supporting the relationship between obesity, diet, alteration in metabolic pathways and prostate cancer.
The emerging role of obesity, diet and lipid metabolism in prostate cancer / Ferro, Matteo; Terracciano, Daniela; Buonerba, Carlo; Lucarelli, Giuseppe; Bottero, Danilo; Perdonà, Sisto; Autorino, Riccardo; Serino, Alessandro; Cantiello, Francesco; Damiano, Rocco; Andras, Iulia; DE PLACIDO, Sabino; DI LORENZO, Giuseppe; Battaglia, Michele; Jereczek Fossa, Barbara A; Mirone, Vincenzo; De Cobelli, Ottavio. - In: FUTURE ONCOLOGY. - ISSN 1479-6694. - (2016). [10.2217/fon-2016-0217]
The emerging role of obesity, diet and lipid metabolism in prostate cancer
FERRO, MATTEO;TERRACCIANO, DANIELA;BUONERBA, CARLO;AUTORINO, RICCARDO;DAMIANO, ROCCO;DE PLACIDO, SABINO;DI LORENZO, GIUSEPPE;MIRONE, VINCENZO;
2016
Abstract
Obesity is associated with an increased risk of a number of serious medical conditions, including cancer. As far as prostate cancer is concerned, obesity is associated with an increased risk of high-grade tumors, which is possibly related to lower androgen levels. Diet may also affect prostate cancer risk since countries with a higher dietary fat intake also present higher prostate cancer mortality rates. Interestingly, prostate cancer is associated with a number of metabolic alterations that may provide valuable diagnostic and therapeutic targets. This review explores the available clinical as well as biological evidence supporting the relationship between obesity, diet, alteration in metabolic pathways and prostate cancer.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
