Glioblastoma multiforme (GBM) develops from a small subpopulation of stem-like cells, which are endowed with the ability to self-renew, proliferate and give rise to progeny of multiple neuroepithelial lineages. These cells are resistant to conventional chemo- and radiotherapy and are hence also responsible for tumor recurrence. HMGA1 overexpression has been shown to correlate with proliferation, invasion, and angiogenesis of GBMs and to affect self-renewal of cancer stem cells from colon cancer. The role of HMGA1 in GBM tumor stem cells is not completely understood.
HMGA1 silencing reduces stemness and temozolomide resistance in glioblastoma stem cells / Colamaio, Marianna; Tosti, Nadia; Puca, Francesca; Mari, Alessia; Gattordo, Rosaria; Kuzay, Yalçın; Federico, Antonella; Pepe, Anna; Sarnataro, Daniela; Ragozzino, Elvira; Raia, Maddalena; Hirata, Hidenari; Gemei, Marica; Mimori, Koshi; DEL VECCHIO, Luigi; Battista, Sabrina; Fusco, Alfredo. - In: EXPERT OPINION ON THERAPEUTIC TARGETS. - ISSN 1472-8222. - 20:10(2016), pp. 1-11-1179. [10.1080/14728222.2016.1220543]
HMGA1 silencing reduces stemness and temozolomide resistance in glioblastoma stem cells
COLAMAIO, MARIANNA;PUCA, FRANCESCA;FEDERICO, ANTONELLA;PEPE, ANNA;SARNATARO, DANIELA;GEMEI, MARICA;DEL VECCHIO, LUIGI;BATTISTA, SABRINA;FUSCO, ALFREDO
2016
Abstract
Glioblastoma multiforme (GBM) develops from a small subpopulation of stem-like cells, which are endowed with the ability to self-renew, proliferate and give rise to progeny of multiple neuroepithelial lineages. These cells are resistant to conventional chemo- and radiotherapy and are hence also responsible for tumor recurrence. HMGA1 overexpression has been shown to correlate with proliferation, invasion, and angiogenesis of GBMs and to affect self-renewal of cancer stem cells from colon cancer. The role of HMGA1 in GBM tumor stem cells is not completely understood.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
