Type 2 diabetes (T2D) and obesity are the major public health problems. Substantial efforts have been made to define loci and variants contributing to the individual risk of these disorders. However, the overall risk explained by genetic variation is very modest. Epigenetics is one of the fastest growing research areas in biomedicine as changes in the epigenome are involved in many biological processes, impact on the risk for several complex diseases including diabetes and may explain susceptibility. In this review, we focus on the role of DNA methylation in contributing to the risk of T2D and obesity.

Epigenetics: spotlight on type 2 diabetes and obesity / Desiderio, A; Spinelli, R; Ciccarelli, M; Nigro, C; Miele, C; Beguinot, F; Raciti, Ga. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 1720-8386. - 39:10(2016), pp. 1095-1103. [10.1007/s40618-016-0473-1]

Epigenetics: spotlight on type 2 diabetes and obesity

Desiderio A;Spinelli R;Beguinot F;RACITI GA
2016

Abstract

Type 2 diabetes (T2D) and obesity are the major public health problems. Substantial efforts have been made to define loci and variants contributing to the individual risk of these disorders. However, the overall risk explained by genetic variation is very modest. Epigenetics is one of the fastest growing research areas in biomedicine as changes in the epigenome are involved in many biological processes, impact on the risk for several complex diseases including diabetes and may explain susceptibility. In this review, we focus on the role of DNA methylation in contributing to the risk of T2D and obesity.
2016
Epigenetics: spotlight on type 2 diabetes and obesity / Desiderio, A; Spinelli, R; Ciccarelli, M; Nigro, C; Miele, C; Beguinot, F; Raciti, Ga. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 1720-8386. - 39:10(2016), pp. 1095-1103. [10.1007/s40618-016-0473-1]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/640748
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