N-Palmitoylethanolamide showed great therapeutic potential in the treatment of inflammation and pain but its unfavourable pharmacokinetics properties will hinder its use in the clinical practice. A nanotechnology-based formulation was developed to enhance the probability of N-palmitoylethanolamide therapeutic success, especially in skin disease management. Lipid nanoparticles were produced and characterized to evaluate their mean size, ζ-potential, thermal behaviour, and morphology. The ability of N-palmitoylethanolamide to diffuse across the epidermis as well as anti-inflammatory and analgesic effects were investigated. Particles had a mean size of about 150nm and a ζ-potential of -40mV. DSC data confirmed the solid state of the matrix and the embedding of N-palmitoylethanolamide while electron microscopy have evidenced a peculiar internal structure (i.e., low-electrondense spherical objects within the matrix) that can be reliably ascribed to the presence of oil nanocompartments. Lipid nanoparticles increased N-palmitoylethanolamide percutaneous diffusion and prolonged the anti-inflammatory and analgesic effects in vivo. Lipid nanoparticles seem a good nanotechnology-based strategy to bring N-palmitoylethanolamide to clinics.

Nanoparticles prolong N-palmitoylethanolamide anti-inflammatory and analgesic effects in vivo / Tronino, Diana; Offerta, Alessia; Ostacolo, Carmine; Russo, Roberto; DE CARO, Carmen; Calignano, Antonio; Puglia, Carmelo; Blasi, Paolo. - In: COLLOIDS AND SURFACES. B, BIOINTERFACES. - ISSN 0927-7765. - 141:(2016), pp. 311-317. [10.1016/j.colsurfb.2016.01.058]

Nanoparticles prolong N-palmitoylethanolamide anti-inflammatory and analgesic effects in vivo

OSTACOLO, CARMINE
Investigation
;
RUSSO, ROBERTO
Investigation
;
DE CARO, CARMEN
Investigation
;
CALIGNANO, ANTONIO
Conceptualization
;
2016

Abstract

N-Palmitoylethanolamide showed great therapeutic potential in the treatment of inflammation and pain but its unfavourable pharmacokinetics properties will hinder its use in the clinical practice. A nanotechnology-based formulation was developed to enhance the probability of N-palmitoylethanolamide therapeutic success, especially in skin disease management. Lipid nanoparticles were produced and characterized to evaluate their mean size, ζ-potential, thermal behaviour, and morphology. The ability of N-palmitoylethanolamide to diffuse across the epidermis as well as anti-inflammatory and analgesic effects were investigated. Particles had a mean size of about 150nm and a ζ-potential of -40mV. DSC data confirmed the solid state of the matrix and the embedding of N-palmitoylethanolamide while electron microscopy have evidenced a peculiar internal structure (i.e., low-electrondense spherical objects within the matrix) that can be reliably ascribed to the presence of oil nanocompartments. Lipid nanoparticles increased N-palmitoylethanolamide percutaneous diffusion and prolonged the anti-inflammatory and analgesic effects in vivo. Lipid nanoparticles seem a good nanotechnology-based strategy to bring N-palmitoylethanolamide to clinics.
2016
Nanoparticles prolong N-palmitoylethanolamide anti-inflammatory and analgesic effects in vivo / Tronino, Diana; Offerta, Alessia; Ostacolo, Carmine; Russo, Roberto; DE CARO, Carmen; Calignano, Antonio; Puglia, Carmelo; Blasi, Paolo. - In: COLLOIDS AND SURFACES. B, BIOINTERFACES. - ISSN 0927-7765. - 141:(2016), pp. 311-317. [10.1016/j.colsurfb.2016.01.058]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/629265
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