Chronic cardiotoxicity is less common in male than in female patients receiving doxorubicin and other anthracyclines at puberty and adolescence. We hypothesized that this sex difference might be secondary to distinct activities of sex hormones on cardiomyocyte senescence, which is thought to be central to the development of long-term anthracycline cardiomyopathy.
Testosterone Antagonizes Doxorubicin-Induced Senescence of Cardiomyocytes / Altieri, Paola; Barisione, Chiara; Lazzarini, Edoardo; Garuti, Anna; Bezante, Gian Paolo; Canepa, Marco; Spallarossa, Paolo; Tocchetti, CARLO GABRIELE; Bollini, Sveva; Brunelli, Claudio; Ameri, Pietro. - In: JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE. - ISSN 2047-9980. - 5:1(2016), p. e002383. [10.1161/JAHA.115.002383]
Testosterone Antagonizes Doxorubicin-Induced Senescence of Cardiomyocytes
TOCCHETTI, CARLO GABRIELE;
2016
Abstract
Chronic cardiotoxicity is less common in male than in female patients receiving doxorubicin and other anthracyclines at puberty and adolescence. We hypothesized that this sex difference might be secondary to distinct activities of sex hormones on cardiomyocyte senescence, which is thought to be central to the development of long-term anthracycline cardiomyopathy.| File | Dimensione | Formato | |
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