The authors report a study in which they evaluate the efficacy of some laboratory parameters for monitoring intrasplenic hepatocyte xenotransplantation (mouse to rat) as an alternative to 99Tc-HIDA dynamic scan and histologic exam. Swiss mouse and wistar rat hepatocytes were obtained with collagenase digestion. Wistar male rats were used as recipient and were allocated into three groups: A) omotransplanted rats; B) xenotransplanted rats; C) xenotransplanted and immunosuppressed (Cyclosporin A: 20 mg/kg/daily orally) rats. All rats underwent > 70% hepatectomy. Blood samples were obtained daily from a femoral vein and AST, ALT, ALP, bilirubin, albumin and urea were measured. No statistical differences were observed among groups and the laboratory parameters tested can't be considered a valid technique to xenotransplant rejection monitoring.

MONITORAGGIO DELLO XENOTRAPIANTO DI EPATOCITI. UTILITA DI ALCUNI PARAMETRI DI LABORATORIO / Lorenzo, M; Angrisani, Luigi; Triassi, Maria; Ventriglia, R.; Savino, B.; Santoro, A.; DI SALVO, Enrico. - In: MINERVA CHIRURGICA. - ISSN 0026-4733. - 50:1-2(1995), pp. 69-73.

MONITORAGGIO DELLO XENOTRAPIANTO DI EPATOCITI. UTILITA DI ALCUNI PARAMETRI DI LABORATORIO

ANGRISANI, LUIGI;TRIASSI, MARIA;DI SALVO, ENRICO
1995

Abstract

The authors report a study in which they evaluate the efficacy of some laboratory parameters for monitoring intrasplenic hepatocyte xenotransplantation (mouse to rat) as an alternative to 99Tc-HIDA dynamic scan and histologic exam. Swiss mouse and wistar rat hepatocytes were obtained with collagenase digestion. Wistar male rats were used as recipient and were allocated into three groups: A) omotransplanted rats; B) xenotransplanted rats; C) xenotransplanted and immunosuppressed (Cyclosporin A: 20 mg/kg/daily orally) rats. All rats underwent > 70% hepatectomy. Blood samples were obtained daily from a femoral vein and AST, ALT, ALP, bilirubin, albumin and urea were measured. No statistical differences were observed among groups and the laboratory parameters tested can't be considered a valid technique to xenotransplant rejection monitoring.
1995
MONITORAGGIO DELLO XENOTRAPIANTO DI EPATOCITI. UTILITA DI ALCUNI PARAMETRI DI LABORATORIO / Lorenzo, M; Angrisani, Luigi; Triassi, Maria; Ventriglia, R.; Savino, B.; Santoro, A.; DI SALVO, Enrico. - In: MINERVA CHIRURGICA. - ISSN 0026-4733. - 50:1-2(1995), pp. 69-73.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/617238
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
social impact