Bovine cutaneous fibropapillomas are benign skin tumours characterized by epithelial and dermal proliferation and induced by Bovine papillomaviruses (BPVs). Cyclooxygenase (COX) 1 and 2 are enzymes involved in pathological conditions, such as inflammation and epithelial carcinogenesis. Here we investigated biochemically and immunohistochemically COX-2 expression in bovine cutaneous fibropapillomas. Eight of twelve fibropapillomas (67%) showed COX-2 positive immunosignal mostly in the cytoplasm of the basal cell layer, while the normal skin did not stain. Biochemical analysis confirmed the expression of COX-2 in tumour samples. This study shows COX-2 expression in cutaneous fibropapillomas, suggesting a contribution in epithelial tumour development.

Expression of Cyclooxygenase-2 in naturally occurring bovine cutaneous fibropapillomas / Bocaneti, F; Altamura, Gennaro; Corteggio, Annunziata; Solcan, C; Velescu, E; Borzacchiello, Giuseppe. - In: POLISH JOURNAL OF VETERINARY SCIENCES. - ISSN 1505-1773. - 18:3(2015), pp. 655-658. [10.1515/pjvs-2015-0084]

Expression of Cyclooxygenase-2 in naturally occurring bovine cutaneous fibropapillomas

ALTAMURA, GENNARO;CORTEGGIO, ANNUNZIATA;BORZACCHIELLO, GIUSEPPE
2015

Abstract

Bovine cutaneous fibropapillomas are benign skin tumours characterized by epithelial and dermal proliferation and induced by Bovine papillomaviruses (BPVs). Cyclooxygenase (COX) 1 and 2 are enzymes involved in pathological conditions, such as inflammation and epithelial carcinogenesis. Here we investigated biochemically and immunohistochemically COX-2 expression in bovine cutaneous fibropapillomas. Eight of twelve fibropapillomas (67%) showed COX-2 positive immunosignal mostly in the cytoplasm of the basal cell layer, while the normal skin did not stain. Biochemical analysis confirmed the expression of COX-2 in tumour samples. This study shows COX-2 expression in cutaneous fibropapillomas, suggesting a contribution in epithelial tumour development.
2015
Expression of Cyclooxygenase-2 in naturally occurring bovine cutaneous fibropapillomas / Bocaneti, F; Altamura, Gennaro; Corteggio, Annunziata; Solcan, C; Velescu, E; Borzacchiello, Giuseppe. - In: POLISH JOURNAL OF VETERINARY SCIENCES. - ISSN 1505-1773. - 18:3(2015), pp. 655-658. [10.1515/pjvs-2015-0084]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/616084
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