Thiazide diuretics have been recommended as a first-line antihypertensive treatment, although the choice of 'the right drug in the individual essential hypertensive patient' remains still empirical. Essential hypertension is a complex, polygenic disease derived from the interaction of patient's genetic background with the environment. Pharmacogenomics could be a useful tool to pinpoint gene variants involved in antihypertensive drug response, thus optimizing therapeutic advantages and minimizing side effects.

TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives / Chittani, Martina; Zaninello, Roberta; Lanzani, Chiara; Frau, Francesca; Ortu, Maria F; Salvi, Erika; Fresu, Giovanni; Citterio, Lorena; Braga, Daniele; Piras, Daniela A; Carpini, Simona Delli; Velayutham, Dinesh; Simonini, Marco; Argiolas, Giuseppe; Pozzoli, Simona; Troffa, Chiara; Glorioso, Valeria; Kontula, Kimmo K; Hiltunen, Timo P; Donner, Kati M; Turner, Stephen T; Boerwinkle, Eric; Chapman, Arlene B; Padmanabhan, Sandosh; Dominiczak, Anna F; Melander, Olle; Johnson, Julie A; Cooper Dehoff, Rhonda M; Gong, Yan; Rivera, Natalia V; Condorelli, Gianluigi; Trimarco, Bruno; Manunta, Paolo; Cusi, Daniele; Glorioso, Nicola; Barlassina, Cristina. - In: JOURNAL OF HYPERTENSION. - ISSN 0263-6352. - 33:6(2015), pp. 1301-9-1309. [10.1097/HJH.0000000000000541]

TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives

TRIMARCO, BRUNO;
2015

Abstract

Thiazide diuretics have been recommended as a first-line antihypertensive treatment, although the choice of 'the right drug in the individual essential hypertensive patient' remains still empirical. Essential hypertension is a complex, polygenic disease derived from the interaction of patient's genetic background with the environment. Pharmacogenomics could be a useful tool to pinpoint gene variants involved in antihypertensive drug response, thus optimizing therapeutic advantages and minimizing side effects.
2015
TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives / Chittani, Martina; Zaninello, Roberta; Lanzani, Chiara; Frau, Francesca; Ortu, Maria F; Salvi, Erika; Fresu, Giovanni; Citterio, Lorena; Braga, Daniele; Piras, Daniela A; Carpini, Simona Delli; Velayutham, Dinesh; Simonini, Marco; Argiolas, Giuseppe; Pozzoli, Simona; Troffa, Chiara; Glorioso, Valeria; Kontula, Kimmo K; Hiltunen, Timo P; Donner, Kati M; Turner, Stephen T; Boerwinkle, Eric; Chapman, Arlene B; Padmanabhan, Sandosh; Dominiczak, Anna F; Melander, Olle; Johnson, Julie A; Cooper Dehoff, Rhonda M; Gong, Yan; Rivera, Natalia V; Condorelli, Gianluigi; Trimarco, Bruno; Manunta, Paolo; Cusi, Daniele; Glorioso, Nicola; Barlassina, Cristina. - In: JOURNAL OF HYPERTENSION. - ISSN 0263-6352. - 33:6(2015), pp. 1301-9-1309. [10.1097/HJH.0000000000000541]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/615262
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 23
  • ???jsp.display-item.citation.isi??? 22
social impact