Weight gain and metabolic changes have been related to survival of early breast cancer patients (EBC). ''However, factors influencing metabolism post-diagnosis are not fully understood. We measured anthropometric [body mass index (BMI), body weight, waist and hip circumferences, and waist-to-hip ratio] and metabolic (levels of insulin, glucose, H1Ac, total, HDL, and LDL cholesterol, triglycerides, and the homeostasis model assessment score [HOMA]) parameters in 433 pre- and post-menopausal women with EBC at diagnosis and 3, 6, 9, 12, and 24 months thereafter. At diagnosis, compared with post-menopausal women, pre-menopausal patients were more likely to be leaner and to have a lower BMI, smaller waist and hip circumferences, and waist-to-hip ratio. They had also lower glucose, HbA1c, and triglyceride levels and a lower HOMA score. Furthermore, they were more likely to have an estrogen- and/or progesterone-positive tumor and a higher proliferating breast cancer. During the first two post-diagnosis years, all women showed a significant increase of weight (+0.72 kg/year, P < 0.001), waist circumference (+1.53 cm/year, P < 0.001), and plasma levels of LDL cholesterol (+5.4 mg/dl per year, P = 0.045) and triglycerides (+10.73 mg/dl per year, P = 0.017). In patients receiving chemotherapy only, there was a significant increase in hip circumference (+3.16 cm/year, P < 0.001) and plasma cholesterol levels (+21.26 mg/dl per year, P < 0.001). We showed that weight, body fat distribution, and lipid profile changed in EBC patients receiving adjuvant therapy. These changes occurred during the first 2 years after diagnosis and were not specifically related to chemotherapy, menopausal status, or initial body weight.

Metabolic and anthropometric changes in early breast cancer patients receiving adjuvant therapy / Arpino, Grazia; DE ANGELIS, Carmine; Buono, Giuseppe; Colao, Annamaria; Giuliano, Mario; Malgieri, Simona; Cicala, Stefania; DE LAURENTIIS, Michelino; Accurso, Antonello; Crispo, Anna; Limite, Gennaro; Lauria, Rossella; Veneziani, BIANCA MARIA; Forestieri, Valeria; Bruzzese, Dario; DE PLACIDO, Sabino. - In: BREAST CANCER RESEARCH AND TREATMENT. - ISSN 0167-6806. - 154:1(2015), pp. 127-32-132. [10.1007/s10549-015-3586-x]

Metabolic and anthropometric changes in early breast cancer patients receiving adjuvant therapy

ARPINO, GRAZIA;DE ANGELIS, CARMINE
Secondo
;
COLAO, ANNAMARIA;GIULIANO, MARIO;MALGIERI, SIMONA;CICALA, STEFANIA;DE LAURENTIIS, MICHELINO;ACCURSO, ANTONELLO;LIMITE, GENNARO;LAURIA, ROSSELLA;VENEZIANI, BIANCA MARIA;FORESTIERI, VALERIA;BRUZZESE, DARIO;DE PLACIDO, SABINO
2015

Abstract

Weight gain and metabolic changes have been related to survival of early breast cancer patients (EBC). ''However, factors influencing metabolism post-diagnosis are not fully understood. We measured anthropometric [body mass index (BMI), body weight, waist and hip circumferences, and waist-to-hip ratio] and metabolic (levels of insulin, glucose, H1Ac, total, HDL, and LDL cholesterol, triglycerides, and the homeostasis model assessment score [HOMA]) parameters in 433 pre- and post-menopausal women with EBC at diagnosis and 3, 6, 9, 12, and 24 months thereafter. At diagnosis, compared with post-menopausal women, pre-menopausal patients were more likely to be leaner and to have a lower BMI, smaller waist and hip circumferences, and waist-to-hip ratio. They had also lower glucose, HbA1c, and triglyceride levels and a lower HOMA score. Furthermore, they were more likely to have an estrogen- and/or progesterone-positive tumor and a higher proliferating breast cancer. During the first two post-diagnosis years, all women showed a significant increase of weight (+0.72 kg/year, P < 0.001), waist circumference (+1.53 cm/year, P < 0.001), and plasma levels of LDL cholesterol (+5.4 mg/dl per year, P = 0.045) and triglycerides (+10.73 mg/dl per year, P = 0.017). In patients receiving chemotherapy only, there was a significant increase in hip circumference (+3.16 cm/year, P < 0.001) and plasma cholesterol levels (+21.26 mg/dl per year, P < 0.001). We showed that weight, body fat distribution, and lipid profile changed in EBC patients receiving adjuvant therapy. These changes occurred during the first 2 years after diagnosis and were not specifically related to chemotherapy, menopausal status, or initial body weight.
2015
Metabolic and anthropometric changes in early breast cancer patients receiving adjuvant therapy / Arpino, Grazia; DE ANGELIS, Carmine; Buono, Giuseppe; Colao, Annamaria; Giuliano, Mario; Malgieri, Simona; Cicala, Stefania; DE LAURENTIIS, Michelino; Accurso, Antonello; Crispo, Anna; Limite, Gennaro; Lauria, Rossella; Veneziani, BIANCA MARIA; Forestieri, Valeria; Bruzzese, Dario; DE PLACIDO, Sabino. - In: BREAST CANCER RESEARCH AND TREATMENT. - ISSN 0167-6806. - 154:1(2015), pp. 127-32-132. [10.1007/s10549-015-3586-x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/615101
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