Hydroxylamine-O-sulfonamide, a molecule incorporating two zincbinding groups (ZBGs), has been investigated as carbonic anhydrase inhibitor (CAI) by means of kinetic, crystallographic and Raman spectroscopy studies, highlighting interesting results on its mechanism of action. These data can be exploited to design new effective and selective CAIs.

HYDROXYLAMINE-O-SULFONAMIDE IS A VERSATILE LEAD COMPOUND FOR THE DEVELOPMENT OF CARBONIC ANHYDRASE INHIBITORS

VERGARA, ALESSANDRO;CATERINO, MARCO;
2015

Abstract

Hydroxylamine-O-sulfonamide, a molecule incorporating two zincbinding groups (ZBGs), has been investigated as carbonic anhydrase inhibitor (CAI) by means of kinetic, crystallographic and Raman spectroscopy studies, highlighting interesting results on its mechanism of action. These data can be exploited to design new effective and selective CAIs.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11588/614427
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